Chinese Hepatolgy ›› 2017, Vol. 22 ›› Issue (3): 219-223.

• Original Articles • Previous Articles    

Effect of nonalcoholic fatty liver disease on intestinal inflammation and permeability

ZHANG Jing-yi,LI Chun-min,TANG Ying-yue,MING Ya-nan,LIU Xiao-lin,ZENG Min-de,MAO Yi-min   

  1. Division of Gastroenterology and Hepatology,Renji Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai Institute of Digestive Disease,Shanghai 200001,China
  • Published:2020-06-22
  • Contact: MAO Yi-min,Email:maoym1968@ 163.com

Abstract: Objective To investigate the effect of nonalcoholic fatty liver disease (NAFLD) on intestinal inflammation and permeability. Methods Twenty-four male rats were equally and randomly divided into control and NAFLD group, which were fed with standard diet and high fat diet for 18 weeks, respectively. The NAFLD rat model was validated by liver histological examination and further grouped by pathological examination of intestinal. Serum levels of diamine oxidase (DAO), D-lactate and endotoxin were detected to evaluate intestinal permeability by enzyme-linked immunosorbent assay. Results Histologically compared with control group, NAFLD group showed macro and micro vesicular fatty degeneration and ballooning, including 7 rats with mild inflammatory cell infiltration in the intestinal tract. By contract, no intestinal inflammation change was detected in control group. Compared with those in control group, serum levels of DAO and D-lactate increased significantly in NAFLD group (P<0.05). Among NAFLD group, the rats with intestinal inflammation showed higher level of D-lactate than that without intestinal inflammation (P<0.05). Furthermore, the plasma lipopolysaccharide-binding protein (LBP) level in NAFLD group with intestinal inflammation was significantly higher than that in control group or NAFLD group without intestinal inflammation (both P<0.05), respectively. Conclusion NAFLD might increase the risk of intestinal inflammation and enhance the intestinal permeability.

Key words: Nonalcoholic fatty liver disease, Intestine, Inflammation, Permeability