Relationship between signal transducer and activator of transcription-3 in placenta and perinatal outcome in patients with intrahepatic cholestasis of pregnancy

Chinese Hepatolgy ›› 2020, Vol. 25 ›› Issue (8): 870-872.

• Other Liver Diseases • Previous Articles Next Articles

Relationship between signal transducer and activator of transcription-3 in placenta and perinatal outcome in patients with intrahepatic cholestasis of pregnancy

PEI Guang-li^1,2, XIE Jie², LIU De-rong², XU Jin'e^*3

1. Qiingdao University, Shandong 266071, China;
2. Obstetrics Department, Linyi Hospital of traditional Chinese Medicine, Linyi, Shandong 266071;
3. Obstetrics Department, Affiliated Hospital of Qingdao University, Qingdao, Shandong 267000, China

Received:2020-04-01 Online:2020-08-31 Published:2020-09-04
Contact: XU Jin'e, Email: xujineqd@163.com

Abstract

Abstract: Objective To investigate the relationship between signal transduction and transcriptional activator 3 (STAT3) in placenta and delivery outcome in pregnant women with intrahepatic cholestasis (ICP) during pregnancy. Methods 126 ICP pregnant women admitted to our hospital from January 2016 to January 2020 were selected as the observation group, and 102 healthy pregnant women admitted to our hospital at the same time were selected as the control group. The expression of STAT3 in placenta was determined by immunohistochemical streptomycin (SP) and western blot.The positive rate of STAT3 cells, the average optical density and the expression of STAT3 protein in placenta of the two groups were compared, and the relationship between the expression of STAT3 in placenta and the delivery outcome of ICP pregnant women was analyzed. Results The positive rate, mean optical density and STAT3 protein expression in the placenta of the observation group were significantly higher than that of the control group (all P<0.001).Among the 126 ICP pregnant women, natural delivery accounted for 30.95% and cesarean section for 69.05%.The positive rate and the average optical density of STAT3 cells in the placenta of the parturient were significantly lower than those of the cesarean section (all P<0.001). Conclusion STAT3 in placenta is closely related to the delivery outcome of ICP pregnant women.

Key words: Signal transducer and activator of transcription 3, Intrahepatic cholestasis of pregnancy, Delivery outcome

PEI Guang-li, XIE Jie, LIU De-rong, XU Jin'e. Relationship between signal transducer and activator of transcription-3 in placenta and perinatal outcome in patients with intrahepatic cholestasis of pregnancy[J]. Chinese Hepatolgy, 2020, 25(8): 870-872.

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Relationship between signal transducer and activator of transcription-3 in placenta and perinatal outcome in patients with intrahepatic cholestasis of pregnancy

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