Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (5): 550-553.

• Other Liver Diseases • Previous Articles     Next Articles

Analysis of the changes of spleen volume and liver fibrosis index in patients with oxaliplatin-induced sinusoidal injury

FU Xue-lin1, DENG Jun1, HUANG Xiao-ning1, LI Wu-gen1, PENG Bi-bo1, LI Chun-lai2, GONG Liang-geng1   

  1. 1. Department of Radiology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China;
    2. Department of Oncology, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China
  • Received:2020-07-30 Online:2021-05-31 Published:2021-06-17
  • Contact: DENG Jun,Email:doctordengjun@163.com

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Abstract: Objective To analyze the characteristic changes of spleen volume and liver fibrosis indexes (APRI, FIB-4) in patients with cancer treated with oxaliplatin as basic chemotherapy regimen during the administration period.Methods A total of 63 patients with gastric cancer and colorectal cancer who received oxaliplatin-based chemotherapy from July 2017 to June 2019 were selected. The data of CT image of upper abdomen, platelet count, AST and ALT in patients before and during chemotherapy were collected. The spleen volume of the patients was measured by post-processing software, and the APRI and FIB-4 values were calculated according to the formulas. Results The spleen volume and liver fibrosis indexes of tumor patients showed a trend of gradual increase during oxaliplatin chemotherapy. The volume of spleen was (196.91±90.63)cm3 before oxaliplatin chemotherapy, and increased to (276.27±135.05)cm3 by the last CT examination during chemotherapy. The speen wolume of 32 (50.8%) patients increased by more than 30%. The APRI and FIB-4 of patients were (0.28±0.15) and (1.28±0.60) before oxaliplatin chemotherapy respectively, which increased to (1.11±0.99) and (3.53±2.15) by the end of the seventh chemotherapy cycle. The values of APRI and FIB-4 increased rapidly during the first three chemotherapy cycles of patients, and then increased slowly; in each chemotherapy cycle, the growth rates of APRI and FIB-4 had a good correlation (P<0.05). There also was a positive correlation between the increased percentage in spleen volume measured at the last CT examination during chemotherapy and the increased percentage in APRI and FIB-4 obtained at the same time (P<0.01), with correlation coefficients of 0.362 and 0.582, respectively.Conclusion Along with the increase of oxaliplatin-based chemotherapy cycle, spleen volume and liver fibrosis indexes (APRI, FIB-4) increased gradually, and could be used as noninvasive biological indexes to monitor the oxaliplatin-induced sinusoidal injury.

Key words: Oxaliplatin, Hepatic sinusoidal obstruction syndrome, Spleen volume, APRI, FIB-4