Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (9): 1027-1030.

• Other Liver Diseases • Previous Articles     Next Articles

Correlation analysis of IL-10, TGF - β and their mRNA levels with liver function indexes in patients with severe acute pancreatitis complicated with liver injury

JIAO Fang-fang, ZHANG Wei, WU Yun-zhen   

  1. Department of Severe Medicine, Dongying People's Hospital, Shandong 257091, China
  • Received:2021-06-21 Online:2021-09-30 Published:2021-10-22

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Abstract: Objective To analyze the correlation between the levels of interleukin-10 (IL-10), transforming growth factor - β (TGFβ) and its transcripts (mRNA) and liver function indexes in patients with severe acute pancreatitis (SAP) complicated with liver injury. Methods 60 SAP patients who were diagnosed and treated in our hospital from October 2018 to October 2020 were included in this trial. According to whether they had liver injury or not, they were divided into combined group (with liver injury) and sap (without liver injury) group, with 30 cases in each group, in addition, 30 healthy volunteers who came to our hospital for physical examination during the same period were included for a controlled study, and the control group was included.The levels of IL-10, TGFβ, IL-10 mRNA, TGFβ mRNA and liver function indexes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), glutamyl transpeptidase (GGT), total bilirubin (TBil)] of the three groups at admission were compared, and the correlation was analyzed by Spearman coefficient. Results The levels of IL-10 and IL-10 mRNA in the combined group were higher than those in the sap group and the control group[(56.74±4.24),(47.58±6.74) vs(39.85±4.36)ng/mL;(1.14±0.21),(0.75±0.14)vs(0.61±0.11)], The levels of TGF - β and TGF - β mRNA in the combined group were significantly higher than those in SAP group and control group[(72.04±8.61)vs(67.54±7.14),(65.38±6.71)ng/L; (0.47±0.08)vs(0.41±0.05),(0.40±0.04)], There was significant difference (P<0.05).The levels of AST, ALT, TBil, GGT and ALP in the combined group were significantly higher than those in SAP group and control group[(85.42±10.24)vs(34.24±5.64),(32.15±5.16)U/L;(79.46±10.41)vs(35.15±4.26),(33.41±4.18)U/L;(40.15±5.42)vs(35.41±4.34),(33.28±4.08)μmol/L,(61.04±7.18)vs(56.34±5.48)U/L,(54.23±4.35)U/L;(116.54±18.41)vs(104.64±12.36),(102.58±11.85)U/L],There was significant difference (P<0.05).The levels of IL-10, IL-10 mRNA, TGFβ and TGF - β mRNA were positively correlated with AST,ALT, GGT, ALP and TBil in SAP patients with liver injury (P<0.05). Conclusion The levels of interleukin-10 (IL-10), transforming growth factor β (TGFβ) and their transcripts (mRNA) were significantly correlated with liver function in SAP patients with liver injury.

Key words: Severe acute pancreatitis, Interleukin-10, Inflammatory mediators transforming growth factor, Liver injury