Chinese Hepatolgy ›› 2021, Vol. 26 ›› Issue (9): 1031-1035.

• Other Liver Diseases • Previous Articles     Next Articles

Non-operative risk factors for postoperative delirium in patients undergoing hepatectomy: a meta-analysis

ZHOU Jing1, LIU Yu-jiao1, GAO Yuan2, HAO Gu3   

  1. 1. Department of General Surgery, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830000, China;
    2. Department of Nursing, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830000, China;
    3. Department of Liver Endoscopic Surgery, the First Hospital Affiliated to Xinjiang Medical University, Urumqi 8300054, China
  • Received:2020-10-30 Online:2021-09-30 Published:2021-10-22

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Abstract: Objective To evaluate non-operative risk factors for postoperative delirium in patients undergoing hepatectomy by Meta-analysis. Methods CNKI, Wanfang, CBM, VIP, PubMed and Embase databases were searched for studies on factors affecting the occurrence of postoperative delirium in patients undergoing hepatectomy from the establishment date of databases to May 7, 2020. And the extracted data were merged and analyzed by using Revman 5.3 software. Results A total of 5 articles and 1181 patients were included. Age: The age in the delirium group was older than that in the non-delirium group with statistical difference (WMD=7.76,95% CI:4.81-10.71, P<0.05). Nutritional indicators: The body mass index (BMI) and albumin level in delirium group were lower than those in non-delirium group with statistical differences (BMI: WMD=-1.19, 95% CI: -2.00--0.39; albumin: WMD=-0.32, 95% CI: -0.42--0.23, P<0.05). Bad life style: There were no statistical differences in incidences of postoperative delirium when comparing smoking group and non-smoking group (OR=0.55,95% CI:0.11-2.78, P>0.05). And there were no statistical differences in incidences of postoperative delirium when comparing alcohol abuse group and non-alcohol abuse group (OR=0.95,95% CI:0.60-1.49, P>0.05). Complications: The incidence of postoperative delirium in the group with pulmonary disease was higher than that in the group without pulmonary disease (OR=3.37, 95% CI: 1.76-6.46, P<0.05). There was were no statistical differences in the incidences of postoperative delirium between the diabetic group and the non-diabetic group, the cardiovascular disease group and the non-cardiovascular disease group (diabetes: OR=0.81, 95% CI: 0.52-1.27, P>0.05; cardiovascular disease: OR=0.98, 95% CI: 0.49-1.94, P>0.05). Sedative drugs: The incidence of postoperative delirium in the group with use of sedative drugs was higher than that in the group without use of sedative drugs (OR=4.31, 95% CI: 2.37-7.81, P<0.05). Conclusion Advanced age, low BMI, lower albumin level, with pulmonary disease and use of sedative drugs are risk factors for postoperative delirium in patients undergoing hepatectomy. For patients undergoing hepatectomy who have the above risk factors, we should pay attention to the occurrence of postoperative delirium, strengthen nutritional support and try to avoid the use of sedative drugs.

Key words: Hepatectomy, Postoperative delirium, Risk factors