An analysis on the correlation between esophageal varices degree and clinical indexes of liver cirrhosis

Abstract

Abstract: Objective To analyze the relationship between the degree of esophageal varices and laboratory indexes of patients with liver cirrhosis, so as to provide reference for clinical diagnosis and prognosis. Methods The clinical information of 175 patients who were diagnosed with liver cirrhosis and underwent gastroscopy in the department of liver cirrhosis of Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine from June 2016 to February 2018 were collected, The correlation between the degree of esophageal varices and laboratory test indexes of these patients were analyzed. Results (1) Compared with patients without esophageal varices (EV), the levels of red blood cell (RBC), hemoglobin (Hb), platelet (PLT), prealbumin (PA), cholinesterase activity (ChE), prothrombin activity (PTA) and fibrinogen (FIB) in the EV group were significantly decreased (P<0.05 or P<0.01); whereas the iver stiffness was significantly increased (22.95 ± 9.85 vs. 18.22 ± 7.94, t=-2.815, P=0.006). (2) With the increase of the degree of EV, the levels of RBC, Hb, PLT, PA and ChE were significantly different among the four groups that were without varices (G0), mild varices (G1), moderate varices (G2) and severe varices (G3) (P<0.05), and RBC, Hb, PLT, PA, ChE, PTA and FIB in G3 group were reduced significantly than those in G0 group (P<0.05 or P<0.01). Correlation analysis showed that the degrees of EV were negatively correlated with the levels of RBC, Hb, PLT, PA, ChE, PTA and FIB (R² = 0.8292, R² = 0.9219, R² = 0.9312, R² = 0.5064, R² = 0.8409, R² = 0.5547, R² = 0.8504, respectively). (3) With the increase of the degrees of EV, the liver hardness value and CTP grade increased gradually. There were significant differences among the four groups (P<0.05), and the degrees of EV were positively correlated with the liver hardness values (R² = 0.9133). Conclusion The degrees of EV in liver cirrhosis are not only related to liver hardness values and CTP scores, but also related to the levels of RBC, Hb, PLT, PA, ChE, PTA and FIB in peripheral blood, which is worthy of clinical attention and -further exploration.

Key words: Cirrhosis, Esophageal varices, Routine blood test, Liver function, Coagulation function, Correlation analysis

LV Ying, JIANG Shi-li, LV Jing, ZHAO Chang-qing, XING Feng, GU Hong-tu, YUAN Ji-li, LIU Cheng-hai, LIU Ping, MU Yong-ping. An analysis on the correlation between esophageal varices degree and clinical indexes of liver cirrhosis[J]. Chinese Hepatolgy, 2022, 27(10): 1096-1101.

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