Chinese Hepatolgy ›› 2023, Vol. 28 ›› Issue (5): 585-589.

• Other Liver Diseases • Previous Articles     Next Articles

The diagnostic value of ultrasound E imaging and MR mDixon sequence in non-alcoholic fatty liver disease

ZHONG Xian-feng1, CHEN Gui'e2, CHEN Yan-chan1, HUANG Jian-yuan3   

  1. 1. Department of Ultrasonic Medicine,Hezhou Traditional Chinese Medicine Hospital, Guangxi 542800, China;
    2. Department of Radiology, Hezhou Traditional Chinese Medicine Hospital,Guangxi 542800, China;
    3. Department of Ultrasound Medicine, The First Affiliated Hospital of Guangxi Medical University,Nanning,530000, China
  • Received:2022-10-24 Online:2023-05-31 Published:2023-08-29
  • Contact: HUANG Jian-yuan,Email:304613543@qq.com

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Abstract: Objective To investigate the diagnostic value of ultrasound E imaging and MR mDixon sequence examination in nonalcoholic fatty liver disease (NAFLD).Methods 147 NAFLD patients (58 mild cases, 59 moderate cases, 30 severe cases) and 125 healthy subjects were diagnosed and treated in our hospital between January 2020 and June 2022, all patients underwent ultrasound E imaging and MR mDixon sequence examination to obtain liver young's modulus and fat content. Spearman correlation analysis was used to evaluate the correlation between the severity of NAFLD and liver young's modulus and fat content. Area under receiver operating characteristic curve (AUC) was used to evaluate the efficacy of young's modulus and fat content in the diagnosis of severe NAFLD.Results AST, ALT, ALP and TBIL in NAFLD patients were (19.62±5.54) IU/L, (27.82±7.10) IU/L, (70.57±7.90) IU/L and (40.72±11.34) μmol/L, respectively, higher than that in healthy subjects [(17.20±5.30) IU/L, (17.54±5.33) IU/L, (67.95±7.82) IU/L and (11.50±5.45) μmol/L, respectively, P<0.05]. AST, ALT, ALP and TBIL in patients with severe NAFLD were (24.64±5.21) IU/L, (30.24±4.00) IU/L, (75.33±10.60) IU/L and (47.43±11.20) μmol/L, respectively, higher than that of patients with moderate NAFLD [(20.50±5.71) IU/L, (29.00±4.87) IU/L, (70.50±10.61) IU/L and (42.56±9.40) μmol/L, respectively, P<0.05] and patients with mild NAFLD [(16.20±3.42) IU/L, (25.31±4.71) IU/L, (67.10±7.55) IU/L and (35.40±8.24) μmol/L, respectively, P<0.05]. Liver young's modulus and fat content in NAFLD patients were (5.30±1.52) kPa and (5.34±1.20) %, respectively, which were higher than those in healthy subjects [(3.04±1.22) kPa and (3.40±1.11) %, respectively, P<0.05)]. Liver Young's modulus and fat content in patients with severe NAFLD were (7.30±1.30) kPa and (6.80±1.23) %, respectively, which were higher than those in patients with moderate NAFLD [5.21±1.41) kPa and (5.50±1.14) %, respectively, P<0.05] and mild NAFLD patients [(4.30±1.32) kPa and (4.21±0.90) %, respectively, P<0.05]. Spearman correlation analysis showed that the severity of NAFLD was positively correlated with liver Young's modulus and fat content (r=0.680, 0.526, P=0.000, 0.000). ROC curve analysis showed that the AUC of young's modulus and fat content in liver in the diagnosis of severe NAFLD was 0.867 and 0.849 respectively, which was lower than that of 0.946 in the combined diagnosis of young's modulus and fat content (P<0.05).Conclusion Ultrasound E imaging and MR mDixon sequence examination can accurately measure young's modulus and fat content of liver, which has high efficacy in diagnosing the severity of NAFLD patients.
   

Key words: Ultrasonic E imaging, MR mDixon sequence, Nonalcoholic fatty liver disease, Young's modulus of liver, Fat content