Expression of chemokine ligand-18 in hepatocellular carcinoma and its influence on the clinicopathological features and prognosis

Abstract

Abstract: Objective To investigate the expression and clinical significance of chemokine ligand-18 (CCL18) in hepatocellular carcinoma (HCC).Methods Forty patients with HCC in our hospital were enrolled. Normal liver tissues adjacent to HCC, as well as normal liver tissues resected from benign liver lesions, were selected as controls. Hepatic expression of CCL18 were detected using immunohistochemistry, and its relationship with clinicopathological features was analyzed. Effect of CCL18 on prognosis of HCC was analyzed using Kaplan-Meier method. Results The positive expression rates of CCL18 in HCC tissues, paracancerous tissues and normal liver tissues were 72.5%, 7.5% and 5.0%, respectively. CCL18 expression significantly increased in patients with poor pathological differentiation and metastasis. The progression-free survival and overall survival in CCL18 negative expression group were significantly higher than those in the positive expression group (P<0.05).Conclusion The positive expression rate of CCL18 was significantly higher in HCC than that in control cases, and closely related to the prognosis. HCC patients with negative hepatic CCL18 might have a longer survival.

Key words: Chemokine ligand-18, Hepatocellular carcinoma, Clinicopathological features, Prognosis

WU Xu-bo, CHANG Qi-meng, WANG Jian-fa, HU Zhi-qiu, SHEN Xiao-dong, ZHANG Zi-ping.. Expression of chemokine ligand-18 in hepatocellular carcinoma and its influence on the clinicopathological features and prognosis[J]. Chinese Hepatolgy, 2018, 23(2): 125-127.

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