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Chinese Hepatolgy    2023, 28 (6): 633-636.   Abstract （122）      PDF （518KB）（159）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (6): 631-633.   Abstract （225）      PDF （512KB）（120）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (8): 885-886.   Abstract （189）      PDF （552KB）（111）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (6): 637-639.   Abstract （74）      PDF （448KB）（105）       Knowledge map    Reference | Related Articles | Metrics

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The changes of platelet parameters and coagulation indexes in patients with cirrhosis and their correlation with upper gastrointestinal bleeding SU Xiao-hong, LI Jing-bo Chinese Hepatolgy    2023, 28 (10): 1171-1174.   Abstract （64）      PDF （390KB）（102）       Knowledge map    Objective To study on the changes of platelet parameters and coagulation indexes in patients with cirrhosis and their correlation with the incidence of upper gastrointestinal bleeding. Methods A retrospective analysis was performed on the medical records of 45 patients with cirrhosis complicated with upper gastrointestinal bleeding admitted from January 2020 to January 2021 (group A), 57 patients with cirrhosis without upper gastrointestinal bleeding (group B), and 49 normal people who received physical examination during the same period of time (group C). The levels of serum platelet count (PLT), mean platelet volume (MPV), platelet volume ratio (PCT), platelet distribution width (PDW), activated partial thrombin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) in the three groups were compared, the correlation between serum PLT, MPV, PCT, PDW, APTT, PT, TT, FIB and upper gastrointestinal bleeding was analyzed by Pearson correlation analysis. Results The levels of PLT, MPV, PCT, and PDW were (301.16±50.24)×109/L, (8.37±1.34) fL, (0.25±0.06)%, and (19.00±1.27)% in group A, which were significantly higher than those of (330.03±55.28)×109/L, (9.38±1.50) fL, (0.35± 0.10)%, and (22.02±1.49)% in group B, and (200.15±40.30)×109/L, (7.18±1.19)fL, (0.18±0.03)%, and (16.36±1.02)% in group C. The levels of PLT, MPV, PCT, PDW in group A were significantly higher than those in group C, the difference were statistically significant (P<0.05); the TT levels in groups A and B were (17.35±0.72)s and (15.25±0.64)s, respectively, which were significantly lower than that of (19.78±1.03)s in group C, The APTT, PT, and FIB levels were (33.15±5.30)s, (12.38±1.50)s, and (4.52±0.74)s in group A, (40.03±6.28)s, (14.37±2.34)s, and (5.66±0.87)s in group B, all were significantly higher than those of (27.16±4.24)s, (11.18±1.09)s, and (3.36±0.40)s in group C. The APTT, PT, and FIB levels in group A were significantly lower, whereas the TT level was significantly higher than those in group B, the differences were statistically significant (P<0.05); Pearson correlation analysis showed that the incidence of upper gastrointestinal hemorrhage was inversely correlated with TT (r=-0.762, P<0.05), whereas positively correlated with PLT, MPV, PCT, PDW, APTT, PT and FIB levels (r=0.618, 0.391, 0.400, 0.537, 0.451, 0.328, and 0.694, respectively, P<0.05). Conclusion The changes of platelet parameters and coagulation indexes in patients with cirrhosis can be used to evaluate the degree and tendency of upper gastrointestinal bleeding, and the monitoring of aboval indexes is of great clinical significance for predicting upper gastrointestinal bleeding. Reference | Related Articles | Metrics

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Predictive value of COSSH-ACLF score combined with serum NLR and AFP for short-term prognosis of acute-on-chronic liver failure after artificial liver support therapy ZHANG Xue, SONG Jie, SHAO Xue Chinese Hepatolgy    2023, 28 (6): 702-706.   Abstract （55）      PDF （574KB）（97）       Knowledge map    Objective To investigate the predictive value of COSSH-ACLF score combined with serum neutrophil/lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) in the short-term prognosis of acute-on-chronic liver failure (ACLF) after artificial liver support therapy. Methods 260 patients with ACLF who successfully received artificial liver support therapy in our hospital from February 2020 to January 2022 were selected retrospectively as the treatment group. Based on whether the patients survived 90 days after treatment, the patients in the treatment group were subdivided into survival group (236 cases) and death group (24 cases). In addition, 260 volunteers who underwent physical examination in our hospital at the same time were selected as the control group. COSSH-ACLF score, NLR and AFP levels were recorded for further analysis. Multivariate logistics regression analysis was used to analyze the risk factors affecting the short-term prognosis of ACLF. ROC curve was used to evaluate the predictive value of COSSH-ACLF score, NLR and AFP on the short-term prognosis of ACLF after artificial liver support therapy. Results The scores of COSSH-ACLF, NLR and AFP in the treatment group were higher than those in the control group (P<0.05); COSSH ACLF score, NLR and AFP in the death group were higher than those in the survival group (P<0.05); The short-term prognosis of ACLF after artificial liver therapy was correlated with serum total bilirubin (TBil), creatinine (Cr), international normalized ratio (INR), MELD score, C-reactive protein (CRP), COSSH-ACLF score, NLR and AFP (P<0.05); Multivariate regression analysis showed that TBil, INR, COSSH-ACLF score, NLR, AFP were the risk factors for short-term prognosis of ACLF treated with artificial liver support therapy (P<0.05). ROC curve showed that the combined prediction of COSSH-ACLF score, NLR, and AFP for short-term prognosis of ACLF had an AUC of 0.877, which was greater than the AUC of individual predictions (P<0.05), and AUC of COSSH ACLF score, NLR, AFP were 0.733, 0.798, 0.794, respectively. Conclusion COSSH ACLF score, NLR and AFP are risk factors for short-term prognosis of patients with ACLF after artificial liver support therapy, and their combined detection has certain predictive value for short-term prognosis of patients with ACLF. Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (10): 1141-1142.   Abstract （66）      PDF （529KB）（95）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (9): 1012-1014.   Abstract （71）      PDF （328KB）（94）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (5): 604-606.   Abstract （41）      PDF （438KB）（92）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (6): 643-645.   Abstract （82）      PDF （489KB）（86）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (8): 1005-1006.   Abstract （48）      PDF （463KB）（83）       Knowledge map    Reference | Related Articles | Metrics

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An analysis on the etiologies and complications of liver cirrhosis in Dali area of China WU Ze-sheng, YAO Qiu-yan, YANG Bo Chinese Hepatolgy    2023, 28 (10): 1167-1170.   Abstract （50）      PDF （415KB）（82）       Knowledge map    Objective To investigate the changing regularity of the etiologies and complications of patients with cirrhosis and decompensated liver function in Dali area in recent 10 years. Methods A retrospective study was conducted to collect the data of patients with liver cirrhosis and decompensated liver function in the First Affiliated Hospital of Dali University in the past 10 years, and to compare the causes and complications between the first five years ( from January 2012 to December 2016) and the last five years (from January 2017 to December 2021). Results There was no statistical difference between the causes of cirrhosis in the last 5 years and the first 5 years. The top 5 causes were alcohol, chronic hepatitis B, schistosomiasis, overlapping causes and cryptogenic cirrhosis. The main causes were alcohol, chronic hepatitis B and schistosomiasis. The proportion of patients with alcoholic liver cirrhosis in the second 5 years was significantly higher than that in the first 5 years (36.8% vs 31.1%), the difference was statistically significant (χ2=7.030, P=0.008), and the proportion of patients with chronic hepatitis B and cryptogenic cirrhosis in the second 5 years was significantly lower than that in the first 5 years (24.4% vs 29.0%, 5.6% vs 7.7%, respectively). The difference was statistically significant (χ2=5.457, P=0.019; χ2=3.844, P=0.050), there was no significant difference between the proportions of patients with schistosomiasis and overlapping causes in the first 5 years and the last 5 years, which were 15.5% vs 14.0%, and 8.0% vs 9.6% (χ2=0.882, P=0.348; χ2=1.600, P=0.206); The most common complications were abdominal effusion and infection. The proportion of patients with complications of abdominal effusion, infection and cholelithiasis in the last 5 years was significantly higher than those in the first 5 years (85.8% vs 73.0%, 47.0% vs 39.3%, and 24.5% vs 16.6%), the difference was statistically significant (χ2=50.824, P<0.001; χ2=11.848, P=0.001; and χ2=18.256, P<0.001), the proportion of patients with gastrointestinal bleeding in the last 5 years was significantly lower than that in the first 5 years (14.3% vs 28.7%), the difference was statistically significant (χ2=62.58, P<0.001). There was no significant difference in the proportion of patients with primary liver cancer (9.6% vs 10.4%, χ2=0.381, P=0.537). Conclusion The main cause of liver cirrhosis and liver function decompensation in Dali area is alcohol, followed by chronic hepatitis B and schistosomiasis. The cirrhosis caused by alcohol is on the rise, while the cirrhosis caused by chronic hepatitis B is in the decline. The most common complications were abdominal effusion and infection, which were on the rise. Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (6): 639-643.   Abstract （75）      PDF （557KB）（82）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (6): 734-737.   Abstract （118）      PDF （536KB）（82）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (5): 505-506.   Abstract （119）      PDF （511KB）（82）       Knowledge map    Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (9): 1127-1130.   Abstract （90）      PDF （1726KB）（77）       Knowledge map    Reference | Related Articles | Metrics

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Construction and validation of the risk prediction model for secondary hepatic encephalopathy in patients with chronic hepatitis B and cirrhosis ZHANG Jia-qi, WANG Zai-chao, YANG Jia-yao, WANG Xiao-meng, ZHAO Yu Chinese Hepatolgy    2023, 28 (8): 916-920.   Abstract （73）      PDF （577KB）（74）       Knowledge map    Objective To investigate the risk factors of secondary hepatic encephalopathy (HE) in patients with chronic hepatitis B (CHB) and cirrhosis, construct a risk prediction model, and verify it.Methods A total of 202 patients with CHB and cirrhosis admitted to the hospital from January 2021 to June 2022 were retrospectively analyzed. According to the presence or absence of secondary HE, the patients were divided into HE group (59 cases) and non-HE group (143 cases). Clinical data of the patients were collected. The risk factors were screened by logistic regression analysis, and a prediction model was constructed. The ROC curve was used to verify the predictive performance of this model.Results Logistic regression analysis results showed that transjugular intrahepatic portosystemic stent-shunts (TIPS, OR=3.043), upper gastrointestinal bleeding (OR=4.007), electrolyte acid-base balance disorder (OR=2.401), hepatorenal syndrome (OR=4.540) and constipation (OR=2.838) were risk factors of secondary HE (P<0.05). The risk prediction model was as follow: P=ex/(1+ex), X=-2.375+1.113×TIPS+1.388×upper gastrointestinal bleeding+0.876×electrolyte acid-base balance disorder+1.513× hepatorenal syndrome+1.043×constipation. The area under the ROC curve (AUC), sensitivity, specificity and Youden index were 0.841 (95%CI=0.772, P<0.001), 80.36%, 80.00% and 0.604, respectively.Conclusion The prediction model can help to better predict the occurrence of HE in patients with CHB and cirrhosis. Clinically, the model can be used to evaluate patients with CHB and cirrhosis, thereby assisting in targeted measures to prevent the occurrence of HE. Reference | Related Articles | Metrics

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Expression and clinical significance of key genes of iron death pathway in liver cancer WANG Xiao, ZHANG Ling-yun Chinese Hepatolgy    2023, 28 (6): 660-664.   Abstract （109）      PDF （4323KB）（73）       Knowledge map    Objective To investigate the expression and prognostic value of key iron death pathway genes in liver cancer and their correlation with the immune microenvironment by bioinformatics. Methods GEPIA online database was used to analyze the expression ferroptosis-related key genes in liver cancer. cBioPortal online database was used to analyze the gene mutation of ferroptosis-related key genes. Kaplan-Meier survival analysis was used to analyze the relationship between ferroptosis-related key genes and prognosis. The TIMER database and the TIDE database were used to analyze the correlation between key genes of the iron death pathway and the immune environment. Results The mRNA expression of ACSL4 was found to be significantly higher in liver cancer tissues than in normal tissues through the GEPIA database (P<0.05). cBioPortal database analysis revealed genetic alterations in key genes of iron death pathway in hepatocellular carcinoma, mainly including gene amplification, deletion mutations, missense mutations and in-frame mutations. Kaplan-Meier survival analysis showed that high GPX4 expression was associated with good prognosis (PFS:HR=0.68, P=0.014) and high expression of SLC7A11 was associated with poor prognosis (OS:HR=2.41, P=5.3e-07; PFS: HR=1.79, P=0.00043). TIMER database analysis showed that SLC7A11 and Nrf2 were positively correlated with infiltration of B cells, CD8+T lymphocytes, CD4+T lymphocytes, neutrophils, macrophages and dendritic cells. Conclusion Iron death pathway key genes are significantly correlated with prognosis and immune cell infiltration in patients with liver cancer, and are potential targets for treatment with important clinical value. Reference | Related Articles | Metrics

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Risk factors and prevention of rebleeding in patients with liver cirrhosis complicated with esophageal and gastric varices bleeding WU Ting, TANG Qi-yuan, LIAO Xue-jiao, LAI Chang-xiang, HE Qing Chinese Hepatolgy    2023, 28 (8): 903-906.   Abstract （86）      PDF （538KB）（72）       Knowledge map    Objective To investigate the risk factors and prevention as well as treatment of rebleeding in patients with liver cirrhosis complicated with esophageal and gastric variceal bleeding (EGVB) in Shenzhen.Methods The clinical data of 548 cases with liver cirrhosis complicated with esophageal and gastric varices in Shenzhen were collected and divided into bleeding group and non-bleeding group according to whether there was bleeding. The age, sex, cause of liver cirrhosis and results of auxiliary examinations (including platelet count, liver function, coagulation function, spleen diameter and ascites, etc.) of the two groups were retrospectively analyzed and compared. The related risk factors of EGVB and the prevention and treatment of rebleeding were investigated.Results The results of univariate analysis showed that there were significant differences in 9 factors, including the cause of liver cirrhosis, Child-Pugh grade, ascites, hepatic encephalopathy and platelet count between the two groups (all P<0.05). Multivariate logistic regression analysis showed that platelet count and albumin were negatively correlated with EGVB (OR value is between 0~1), and ascites was positively correlated with EGVB (OR value is 3.068). In the bleeding group, 109 cases (about 51.4%) received prophylactic treatment for rebleeding, including 90 cases of endoscopic therapy, 2 cases of surgical therapy, 1 case of interventional therapy and liver transplantation, and 15 cases of combined therapy.Conclusion Patients with esophageal and gastric varices who with ascites in Shenzhen may be more prone to variceal bleeding, which should be paid attention to in clinical practice. At the same time, attention should be paid to clinical protective measures, and if necessary, normative secondary prevention and treatment should be feasible. Reference | Related Articles | Metrics

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Chinese Hepatolgy    2023, 28 (8): 897-902.   Abstract （107）      PDF （1232KB）（71）       Knowledge map    Reference | Related Articles | Metrics