Most Down Articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

In last 2 years

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Chinese Hepatolgy    2023, 28 (6): 633-636.   Abstract （349）      PDF （518KB）（231）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (6): 734-737.   Abstract （362）      PDF （536KB）（178）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (6): 631-633.   Abstract （417）      PDF （512KB）（173）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (9): 1127-1130.   Abstract （222）      PDF （1726KB）（173）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (11): 1372-1374.   Abstract （377）      PDF （493KB）（172）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (6): 724-727.   Abstract （284）      PDF （533KB）（170）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (6): 637-639.   Abstract （224）      PDF （448KB）（166）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (6): 737-739.   Abstract （394）      PDF （413KB）（165）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2024, 29 (3): 258-259.   Abstract （148）      PDF （395KB）（165）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2024, 29 (3): 255-257.   Abstract （161）      PDF （486KB）（159）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (8): 885-886.   Abstract （316）      PDF （552KB）（159）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2024, 29 (1): 9-12.   Abstract （96）      PDF （477KB）（152）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2024, 29 (1): 5-9.   Abstract （130）      PDF （608KB）（151）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (9): 1012-1014.   Abstract （171）      PDF （328KB）（149）       Knowledge map    Reference | Related Articles | Metrics

Select

Predictive value of COSSH-ACLF score combined with serum NLR and AFP for short-term prognosis of acute-on-chronic liver failure after artificial liver support therapy ZHANG Xue, SONG Jie, SHAO Xue Chinese Hepatolgy    2023, 28 (6): 702-706.   Abstract （125）      PDF （574KB）（146）       Knowledge map    Objective To investigate the predictive value of COSSH-ACLF score combined with serum neutrophil/lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) in the short-term prognosis of acute-on-chronic liver failure (ACLF) after artificial liver support therapy. Methods 260 patients with ACLF who successfully received artificial liver support therapy in our hospital from February 2020 to January 2022 were selected retrospectively as the treatment group. Based on whether the patients survived 90 days after treatment, the patients in the treatment group were subdivided into survival group (236 cases) and death group (24 cases). In addition, 260 volunteers who underwent physical examination in our hospital at the same time were selected as the control group. COSSH-ACLF score, NLR and AFP levels were recorded for further analysis. Multivariate logistics regression analysis was used to analyze the risk factors affecting the short-term prognosis of ACLF. ROC curve was used to evaluate the predictive value of COSSH-ACLF score, NLR and AFP on the short-term prognosis of ACLF after artificial liver support therapy. Results The scores of COSSH-ACLF, NLR and AFP in the treatment group were higher than those in the control group (P<0.05); COSSH ACLF score, NLR and AFP in the death group were higher than those in the survival group (P<0.05); The short-term prognosis of ACLF after artificial liver therapy was correlated with serum total bilirubin (TBil), creatinine (Cr), international normalized ratio (INR), MELD score, C-reactive protein (CRP), COSSH-ACLF score, NLR and AFP (P<0.05); Multivariate regression analysis showed that TBil, INR, COSSH-ACLF score, NLR, AFP were the risk factors for short-term prognosis of ACLF treated with artificial liver support therapy (P<0.05). ROC curve showed that the combined prediction of COSSH-ACLF score, NLR, and AFP for short-term prognosis of ACLF had an AUC of 0.877, which was greater than the AUC of individual predictions (P<0.05), and AUC of COSSH ACLF score, NLR, AFP were 0.733, 0.798, 0.794, respectively. Conclusion COSSH ACLF score, NLR and AFP are risk factors for short-term prognosis of patients with ACLF after artificial liver support therapy, and their combined detection has certain predictive value for short-term prognosis of patients with ACLF. Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2024, 29 (2): 143-146.   Abstract （131）      PDF （597KB）（141）       Knowledge map    Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (10): 1141-1142.   Abstract （174）      PDF （529KB）（140）       Knowledge map    Reference | Related Articles | Metrics

Select

The changes of platelet parameters and coagulation indexes in patients with cirrhosis and their correlation with upper gastrointestinal bleeding SU Xiao-hong, LI Jing-bo Chinese Hepatolgy    2023, 28 (10): 1171-1174.   Abstract （169）      PDF （390KB）（140）       Knowledge map    Objective To study on the changes of platelet parameters and coagulation indexes in patients with cirrhosis and their correlation with the incidence of upper gastrointestinal bleeding. Methods A retrospective analysis was performed on the medical records of 45 patients with cirrhosis complicated with upper gastrointestinal bleeding admitted from January 2020 to January 2021 (group A), 57 patients with cirrhosis without upper gastrointestinal bleeding (group B), and 49 normal people who received physical examination during the same period of time (group C). The levels of serum platelet count (PLT), mean platelet volume (MPV), platelet volume ratio (PCT), platelet distribution width (PDW), activated partial thrombin time (APTT), prothrombin time (PT), thrombin time (TT) and fibrinogen (FIB) in the three groups were compared, the correlation between serum PLT, MPV, PCT, PDW, APTT, PT, TT, FIB and upper gastrointestinal bleeding was analyzed by Pearson correlation analysis. Results The levels of PLT, MPV, PCT, and PDW were (301.16±50.24)×109/L, (8.37±1.34) fL, (0.25±0.06)%, and (19.00±1.27)% in group A, which were significantly higher than those of (330.03±55.28)×109/L, (9.38±1.50) fL, (0.35± 0.10)%, and (22.02±1.49)% in group B, and (200.15±40.30)×109/L, (7.18±1.19)fL, (0.18±0.03)%, and (16.36±1.02)% in group C. The levels of PLT, MPV, PCT, PDW in group A were significantly higher than those in group C, the difference were statistically significant (P<0.05); the TT levels in groups A and B were (17.35±0.72)s and (15.25±0.64)s, respectively, which were significantly lower than that of (19.78±1.03)s in group C, The APTT, PT, and FIB levels were (33.15±5.30)s, (12.38±1.50)s, and (4.52±0.74)s in group A, (40.03±6.28)s, (14.37±2.34)s, and (5.66±0.87)s in group B, all were significantly higher than those of (27.16±4.24)s, (11.18±1.09)s, and (3.36±0.40)s in group C. The APTT, PT, and FIB levels in group A were significantly lower, whereas the TT level was significantly higher than those in group B, the differences were statistically significant (P<0.05); Pearson correlation analysis showed that the incidence of upper gastrointestinal hemorrhage was inversely correlated with TT (r=-0.762, P<0.05), whereas positively correlated with PLT, MPV, PCT, PDW, APTT, PT and FIB levels (r=0.618, 0.391, 0.400, 0.537, 0.451, 0.328, and 0.694, respectively, P<0.05). Conclusion The changes of platelet parameters and coagulation indexes in patients with cirrhosis can be used to evaluate the degree and tendency of upper gastrointestinal bleeding, and the monitoring of aboval indexes is of great clinical significance for predicting upper gastrointestinal bleeding. Reference | Related Articles | Metrics

Select

Clinical efficacy of DPMAS combined with PE in the treatment of liver failure YANG Hang, LUO Yong-yan, PAN Lu-da, ZHANG Lue-tao, SONG Su-na Chinese Hepatolgy    2023, 28 (6): 707-710.   Abstract （320）      PDF （561KB）（136）       Knowledge map    Objective To study the curative effect of double plasma molecular adsorption system (DPMAS) combined with plasma exchange (PE) on patients with liver failure. Methods A total of 138 patients with liver failure from October 2018 to May 2022 were enrolled. The patients were randomly divided into DPMAS group(Group A), PE group(Group B) and DPMAS+ PEgroup(Group C) with 46 cases in each group. The changes of liver function indexes (AST, ALT, TBil), the serum cytokines (TNF-α, IFN-γ and IL-6) and coagulation function (PT, INR, PTA) in the 3 groups were collected. Results On the 90th day of treatment, managment in Group C was assessed as markedly effective in 22 cases, effective in 14 cases and ineffective in 3 cases. 7 cases died during the treatment. The intervention outcomes for Group C outperformed those of both Group A(which had 12 effective cases, 19 effective cases, 3 ineffective cases and 12 deaths) and Group B(which had 11 effective cases, 18 effective cases, 3 ineffective cases, 14 deaths) (Z=-2.044, -2.408; P=0.041, 0.016). On the 28th and 90th of treatment, the levels of TBil in Group B[(201.1±77.4) μmol/L and (93.6±28.2) μmol/L, respectively] were significantly higher than those in Group A [(157.9±56.2) μmol/L and (80.2±21.7) μmol/L] and Group C [(162.7±50.2) μmol/L and (78.6±24.6) μmol/L, F=6.630、5.004,P=0.002、0.008]. On the 90th day of treatment, the serum levels of TNF-α, IFN-γ and IL-6 in Group C[(20.6±14.4) pg/mL, (32.4±13.8) pg/mL and (31.7±10.1) ng/L, respectively] were significantly lower than those in group A [(34.2±16.2) pg/mL, (43.2±18.4) pg/mL and (48.7±14.4) ng/L] and group B [(35.7±17.3) pg/mL, (40.6±17.6) pg/mL and (50.0±12.8) ng/L]. F=12.417、5.228、30.406,all P<0.05]. On the 90th day of treatment, PT and INR in Group A[(18.3±3.8) s and (1.23±0.11), respectively] were significantly higher than those in Group B [(15.1±3.6) s and (1.10±0.09)] and Group C [(14.6±3.9) s and (1.07±0.27), F=13.052、10.722,P=0.000、0.000]. Conclusion The DPMAS sequential PE therapy for patients with liver failure effectively leverages the strengths of both DPMAS and PE. It is capable of clearing cytokines, improving coagulation disorder, safeguarding liver function and thereby enhancning the overal therapeutic efficacy. Reference | Related Articles | Metrics

Select

Chinese Hepatolgy    2023, 28 (5): 604-606.   Abstract （121）      PDF （438KB）（131）       Knowledge map    Reference | Related Articles | Metrics