关键词: 乙型肝炎病毒, 乙型肝炎表面抗原, 特高高原, 藏族,农牧民

Abstract: Objective To investigate the prevalence of hepatitis B surface antigen (HBsAg) among Tibetan peasants and herdsmen in high-altitude plateau of more than 4,500 meters.Methods It was retrospectively analyzed that Tibetan peasants and herdsmen received health examinations with measurements of hepatitis B virus serum markers (HBV-M) or single HBsAg, as well as patients from hospital in Gamba from 2014 to 2015. Results There were 904 peasants and herdsmen from 5 towns with the HBsAg positive rate as 20.0% (95% CI: 17.4%~22.6%), ranging from 14.1% to 30.0%. HBsAg positive rates of out-patients (n=299) and in-patients (n=299) from Gamba hospital were 24.7% (95% CI: 22.3%~32.5%) and 26.4% (95% CI: 21.4%~31.4%), respectively. There were 181 patients receiving HBV-M detection with 58.6% (95% CI: 51.4%~65.8%) showing negative results. Conclusion Tibetan peasants and herdsmen showed high HBsAg positive rate and low protection rate of HBV vaccine in Gamba, which suggests that more attention should be payed to HBV infection.

Key words: Hepatitis B virus, Hepatitis B surface antigen, Extreme altitude, Tibetan peasants and herdsmen