IgG4与免疫性肝损伤疾病的关系

肝脏 ›› 2018, Vol. 23 ›› Issue (12): 1078-1080.

IgG4与免疫性肝损伤疾病的关系

王兰, 邱红, 杨瑞宁

210002 南京中医药大学附属南京八一医院检验科

收稿日期:2018-07-16 发布日期:2020-04-29
通讯作者: 杨瑞宁

Preliminary exploration of the relationship between IgG4 and immunological liver injury

WANG Lan, QIU Hong, YANG Rui-ning

Laboratory Department of Nanjing 81th Hospital Affiliated to Nangjing University of Traditional Chinese Medicine, Jiangsu 210002, China

Received:2018-07-16 Published:2020-04-29
Contact: YANG Rui-ning

摘要/Abstract

摘要： 目的探讨血清IgG4水平与不同类型免疫性肝损伤的相关性及临床意义。方法收集解放军八一医院免疫性肝损伤患者220例,其中慢性乙型肝炎(CHB)80例,自身免疫性肝炎(AIH)60例、原发性胆汁性肝硬化(PBC)80例。回顾性分析3组患者的血清生化指标、血清IgG4水平、自身抗体等差异。分析IgG4与各类疾病的相关性。结果 AIH组IgG4水平为3.24(1.78~4.53),相对于其他两组升高最为明显(P<0.05),PBC组IgG4水平为2.19(0.69~3.01),高于CHB组的1.40(0.55~3.05),但低于AIH组。组内分析发现,血清IgG4水平与患者肝功能、自身抗体阳性率具有一定相关性。结论 AIH与IgG4含量的相关性最明显,IgG4含量的检测对辅助诊断AIH等免疫性肝损伤以及疗效具有一定意义。

关键词: IgG4, 免疫性肝损伤

Abstract: Objective To analyze the level of immunoglobulin G4 (IgG4) in serum from patients with 3 types of immunological liver injury, and to investigate its correlation with different types of immunological liver injury and the clinical significance. Methods A total of 220 patients with immunological liver injury in our hospital were enrolled, including 80 patients with chronic hepatitis B (CHB), 60 patients with autoimmune hepatitis (AIH) and 80 patients with primary biliary cirrhosis (PBC). The serum biochemical index, serum IgG4 level and autoantibodies of the 3 groups were retrospectively analyzed for comparative analysis of the relationship between IgG4 and diseases. Results The median level of IgG4 in AIH group was 3.24 (1.78~4.53), which was significantly higher than that in other 2 groups (P<0.05). The median level of IgG4 in PBC group was 2.19 (0.69~3.01), which was higher than that in CHB group (1.40) (0.55~3.05). Within the group, serum IgG4 levels showed a certain correlation with liver function and autoantibody positive rate. Conclusion The correlation between AIH and IgG4 is the most relevant among the 3 groups. Thus, detection of IgG4 content is of great significance in the diagnosis of immunological liver injury, such as AIH, and the evaluation of therapeutic effect.

Key words: Immunoglobulin G4;Immunological liver injury

王兰, 邱红, 杨瑞宁. IgG4与免疫性肝损伤疾病的关系[J]. 肝脏, 2018, 23(12): 1078-1080.

WANG Lan, QIU Hong, YANG Rui-ning. Preliminary exploration of the relationship between IgG4 and immunological liver injury[J]. Chinese Hepatolgy, 2018, 23(12): 1078-1080.

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