关键词: 何首乌, 药物性肝损伤, 临床特点

Abstract: Objective To analyze the clinical characteristics of acute liver injury induced by Polygonum multiflorum retrospectively.Methods Patients diagnosed of Polygonum multiflorum induced liver injury at discharge in our hospital from January 2012 to December 2017 were included, and their medical records and prognosis were collected and analyzed.Results There were 39 patients in the study, including 28 cases (71.79%) receiving Polygonum multiflorum compound preparations. The symptoms of most patients appeared within 1 month and no more than 3 months. Liver aminotransferase, bilirubin and coagulation were significantly abnormal in the patients. All patients receiving Polygonum multiflorum monotherapy and the majority (89.29%) of patients taking Polygonum multiflorum compound preparations were with hepatocellular injury type. Alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin and other biochemical indicators of most patients were normalized within 7 days after treatment. No liver failure or death occurred in all patients.Conclusion Clinicians should pay attention to the acute liver injury induced by Polygonum multiflorum. The liver function of patients receiving Polygonum multiflorum should be examined within 3 months.

Key words: Polygonum multiflorum, Drug-induced liver injury, Clinical characteristics