原发性肝癌患者肿瘤标志物、IGF-1的检测及相关危险因素分析

肝脏 ›› 2020, Vol. 25 ›› Issue (10): 1079-1082.

原发性肝癌患者肿瘤标志物、IGF-1的检测及相关危险因素分析

石光英, 周芳, 王红霞, 谢敬东

830002 乌鲁木齐新疆生产建设兵团医院消化肝病科(石光英); 新疆医科大学学报(周芳); 昌吉州人民医院消化内科(王红霞); 上海交通大学医学院附属瑞金医院感染科(谢敬东)

收稿日期:2020-05-22 出版日期:2020-10-31 发布日期:2020-12-18
通讯作者: 谢敬东, Email:shigy5715695@126.com
基金资助:
新疆兵团科技计划项目(2016AD011)

Tumor markers, IGF-1 and risk factors in patients with primary liver cancer

SHI Guang-ying¹, ZHOU Fang², WANG Hong-xia³, XIE Jing-dong⁴

1. Department of Gastroenterology, Xinjiang Production and Construction Corps Hospital, Urumqi 830002, China;
2. Journal of Xinjiang Medical University, Urumqi 830018, China;
3. Department of Gastroenterology, Changjizhou People's Hospital, Changji 831118, China;
4. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2020-05-22 Online:2020-10-31 Published:2020-12-18
Contact: XIE Jing-dong, Email:shigy5715695@126.com

摘要/Abstract

摘要： 目的检测原发性肝癌患者肿瘤标志物胰岛素样生长因子(IGF-1)的水平,并分析相关危险因素。方法回顾性分析2015年6月—2017年12月新疆生产建设兵团医院、新疆医科大学第一附属医院医院及昌吉州人民医院收治的原发性肝癌患者120例,依据是否合并糖尿病分为肝癌合并糖尿病组(n=60)和肝癌未合并糖尿病组(n=60)。检测两组患者肝功能、肿瘤标志物及IGF-1、IGFBP-3水平。采用多元logistic回归分析法分析原发性肝癌的危险因素。结果肝癌合并糖尿病组与肝癌未合并糖尿病组患者肝功能AST、ALT及TBil水平比较差异无统计学意义(P>0.05)。肝癌合并糖尿病组与肝癌未合并糖尿病组患者肿瘤标志物AFP及CA19-9水平比较差异无统计学意义(P>0.05)。肝癌合并糖尿病组IGF-1、IGFBP-3水平明显低于肝癌未合并糖尿病组(P<0.05)。HBV感染、饮酒、糖尿病、恶性肿瘤家族史和吸烟均为原发性肝癌的独立危险因素(P<0.05)。结论糖尿病可能会提高原发性肝癌的发生率,尤其是HBV感染、饮酒、恶性肿瘤家族史和吸烟的患者,需多关注糖尿病合并原发性肝癌患者的治疗。

关键词: 原发性肝癌, 糖尿病, IGF-1, 危险因素, logistic回归分析

Abstract: Objective To investigate the levels of tumor markers and insulin-like growth factor 1 (IGF-1) in patients with primary liver cancer, and to determine risk factors for primary liver cancer. Methods There were 120 primary liver cancer patients treated in Xinjiang Production and Construction Corps Hospital, the First Affiliated Hospital of Xinjiang Medical University and Changji People's Hospital from June 2015 to December 2017 enrolled in the retrospective analysis, including 60 cases with diabetes and 60 cases without. Liver function, tumor markers, IGF-1 and insulin-like growth factor binding protein 3 (IGFBP-3) levels were detected in both groups. Multivariate logistic regression analysis was performed to analyze the risk factors for primary liver cancer. Results There was no significant difference in the levels of aspartate aminotransferase, alanine aminotransferase, total bilirubin, alpha-fetoprotein and carbohydrate antigen 19-9 between primary liver cancer patients with and without diabetes (P>0.05). The levels of IGF-1 and IGFBP-3 in patients with diabetes were significantly lower than those in patients without (P<0.05). Hepatitis B virus infection, alcohol consumption, diabetes, family history of malignant tumors and smoking were independent risk factors for primary liver cancer (P<0.05). Conclusion Diabetic patients have a higher risk of developing primary liver cancer.

Key words: Primary liver cancer, Diabetes, Insulin-like growth factor-1, Risk factors, Logistic regression analysis

石光英, 周芳, 王红霞, 谢敬东. 原发性肝癌患者肿瘤标志物、IGF-1的检测及相关危险因素分析[J]. 肝脏, 2020, 25(10): 1079-1082.

SHI Guang-ying, ZHOU Fang, WANG Hong-xia, XIE Jing-dong. Tumor markers, IGF-1 and risk factors in patients with primary liver cancer[J]. Chinese Hepatolgy, 2020, 25(10): 1079-1082.

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