常规超声联合LAMP2、ARFI在PBC患者肝纤维化程度监测中的价值

肝脏 ›› 2020, Vol. 25 ›› Issue (10): 1101-1104.

常规超声联合LAMP2、ARFI在PBC患者肝纤维化程度监测中的价值

常隽, 张文婷

210006 江苏南京医科大学附属南京医院(南京市第一医院) 功能检查科

收稿日期:2020-03-26 出版日期:2020-10-31 发布日期:2020-12-18
通讯作者: 张文婷

The value of routine ultrasound combined with LAMP 2 and ARFI in monitoring the degree of liver fibrosis in PBC patients

CHANG Jun, ZHANG Wen-ting

Department of Functional Examination, Nanjing Hospital Affiliated to Nanjing Medical University (Nanjing First Hospital), Jiangsu 210006, China

Received:2020-03-26 Online:2020-10-31 Published:2020-12-18
Contact: ZHANG Wen-ting

摘要/Abstract

摘要： 目的分析常规超声联合溶酶体膜蛋白2(LAMP2)、声辐射力脉冲成像(ARFI)在PBC患者肝纤维化程度监测中的价值。方法选择2016年2月至2019年4月在本院进行治疗的,经肝穿刺病理组织学检查确诊为PBC的96例患者的完整资料进行回顾性分析,另随机选取在本院进行健康体检的患者60例作为对照组。入组研究对象均行常规超声检查,免疫组化法检测LAMP2表达水平,检测各组ARFI。结果 PBC患者ARFI,LAMP2和超声积分均高于对照组,统计学分析结果表明差异有统计学意义(P<0.05)。F检验结果表明在不同Child-Pugh分级的PBC患者之间,ARFI,LAMP2和超声积分存在显著差异(P<0.05)。t检验结果表明,Child-Pugh为B级的患者ARFI,LAMP2和超声积分均显著高于A级患者(P<0.05),Child-Pugh为C级的患者ARFI,LAMP2和超声积分均显著高于A级和B级患者(P<0.05)。LAMP2、ARFI及超声积分与PBC患者Child-Pugh分级均呈显著正相关 (P<0.05)。结论常规超声联合LAMP2、ARFI可准确评估PBC患者肝纤维化程度,具有较高的诊断价值。

关键词: 常规超声, LAMP2, ARFI, PBC, 肝纤维化

Abstract: Objective To analyze the value of conventional ultrasound combined with LAMP2,ARFI in monitoring the degree of hepatic fibrosis in patients with PBC. Methods The complete data of 96 patients with PBC diagnosed by liver puncture and pathology from February 2016 to April 2019 were analyzed retrospectively. in addition, 60 patients who underwent physical examination in our hospital were randomly selected as the control group. All the subjects were examined by routine ultrasound, the expression of LAMP2 was detected by immunohistochemistry, and the ARFI. of each group was detected also. Results The scores of ARFI,LAMP2 and ultrasound images in PBC patients were significantly higher than those in control group (P < 0.05). The results of F test showed that there were significant differences in ARFI,LAMP2 and ultrasound scores among PBC patients with different Child-Pugh grades. T test showed that ARFI,LAMP2 and ultrasound scores in patients with grade B Child-Pugh were significantly higher than those in patients with grade A. ARFI,LAMP2 and ultrasound scores in patients with Child-Pugh grade C were significantly higher than those in patients with grade A and B (P < 0.05). LAMP2, ARFI and ultrasound scores were positively correlated with Child-Pugh grade in patients with PBC (P<0.05). Conclusion Conventional ultrasound combined with LAMP2,ARFI can accurately evaluate the degree of hepatic fibrosis in patients with PBC, and has high diagnostic value.

Key words: conventional ultrasound, LAMP2, ARFI, PBC, liver fibrosis

常隽, 张文婷. 常规超声联合LAMP2、ARFI在PBC患者肝纤维化程度监测中的价值[J]. 肝脏, 2020, 25(10): 1101-1104.

CHANG Jun, ZHANG Wen-ting. The value of routine ultrasound combined with LAMP 2 and ARFI in monitoring the degree of liver fibrosis in PBC patients[J]. Chinese Hepatolgy, 2020, 25(10): 1101-1104.

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