三维适形放疗联合TACE治疗中晚期肝癌患者的早期疗效

肝脏 ›› 2020, Vol. 25 ›› Issue (12): 1269-1271.

三维适形放疗联合TACE治疗中晚期肝癌患者的早期疗效

郭萍, 袁志平

646000 四川泸州西南医科大学研究生院(郭萍,袁志平);宜宾市第二人民医院肿瘤科(袁志平)

收稿日期:2020-02-20 出版日期:2020-12-31 发布日期:2021-02-26
通讯作者: 袁志平,Email:3486594870@qq.com
基金资助:
四川省教育厅重点科研项目(07ZA030)

Early effect of three-dimensional conformal radiotherapy on liver cancer patients received transcatheter arterial chemoembolization therapy

GUO Ping¹, YUAN Zhi-ping^1,2

1. Graduate School of Southwest Medical University, Luzhou 646000, Sichuan, China;
2. Department of Oncology, Second People's Hospital of Yibin 644000, Yibin, China

Received:2020-02-20 Online:2020-12-31 Published:2021-02-26
Contact: YUAN Zhi-ping,Email:3486594870@qq.com

摘要/Abstract

摘要： 目的探究三维适形放疗联合经导管动脉栓塞化疗(TACE)对中晚期肝癌患者的早期临床疗效。方法回顾性选择2015年7月至2018年7月我院收治的原发性肝癌患者,按照接受的治疗方法不同分为联合组(n=56)与单纯TACE组(n=68)。联合组接受TACE与三维适形放疗联合治疗,单纯TACE组仅接受TACE治疗。观察两组治疗后早期临床疗效、毒副反应,随访1年后两组存活情况。结果联合组早期治疗有效率为73.21%(41/56)高于单纯TACE组早期有效率52.94%(36/68)(P<0.05)。联合组中放疗期间总放疗毒副反应发生率为33.93%(19/56),其中发生急性放射性胃炎、急性放射性肝损伤、白细胞计数低于2.5×10⁹/L的患者各1例,占比1.79%(1/56),两组治疗1年后总存活率比较无显著差异(P>0.05)。结论对于中晚期肝癌患者,在TACE基础上增加三维适形放疗治疗能明显提高早期临床疗效,无严重放疗不良反应,具有良好安全性。

关键词: 三维适形, 放疗, 肝癌, TACE, 临床疗效

Abstract: Objective To investigate the early effect of three-dimensional conformal radiotherapy on liver cancer patients with transcatheter arterial chemoembolization (TACE).Methods One hundred and twenty-four patients with advanced primary liver cancer were retrospectively selected in this study, They were divided into combined group (n=56) and simple TACE group (n=68) according to the treatment they had received. The early clinical efficacy, adverse reactions, and survival rate were observed in 1-year's follow-up period of time.Results The early effective rate of the combined group was higher than that of the TACE group (73.21% vs 52.94%, P<0.05). The incidence of total toxicity and side effects during radiotherapy in the combined group was 33.93%, including 1 case (1.79%) of acute radiation gastritis, 1 case (1.79%) of acute radiation liver injury, 1 case (1.79%) of leucocytes count lower than 2.5×10⁹/L. There was no significant difference in overall survival rate between the two groups at 1 year after the treatment (P>0.05).Conclusion For patients with advanced liver cancer, TACE combined with three-dimensional conformal radiotherapy can effectively improve the early clinical efficacy, without severe radiotherapy toxicity and side effects.

Key words: 3D conformal radiotherapy, Radiation therapy, Liver cancer, Transcatheter arterial chemoembolization, Clinical effect

郭萍, 袁志平. 三维适形放疗联合TACE治疗中晚期肝癌患者的早期疗效[J]. 肝脏, 2020, 25(12): 1269-1271.

GUO Ping, YUAN Zhi-ping. Early effect of three-dimensional conformal radiotherapy on liver cancer patients received transcatheter arterial chemoembolization therapy[J]. Chinese Hepatolgy, 2020, 25(12): 1269-1271.

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