HBsAg定量在乙型肝炎相关性肝癌患者中检测的临床意义

摘要/Abstract

摘要： 目的: 探讨乙型肝炎表面抗原(HBsAg)定量在乙型肝炎肝硬化和肝硬化并发肝细胞癌(HCC)患者中的变化,以期为乙型肝炎相关性肝癌的早期诊断提供临床指导意义。方法: 采用回顾性分析方法,选取我院乙型肝炎肝硬化并发肝癌患者54例,选取同期住院的单纯乙型肝炎肝硬化患者72例作为对照,分析两组患者HBsAg定量和HBV DNA定量水平的差异。结果: 乙型肝炎相关性肝癌患者HBsAg定量及HBV DNA 水平均明显低于单纯乙型肝炎肝硬化患者,差异有统计学意义(P<0.001)。结论: HBsAg定量在肝硬化进展为肝细胞癌的过程中逐渐下降,HBsAg定量可以作为肝细胞癌发生和发展的预测因素,为乙型肝炎相关性肝癌的早期诊断提供临床意义。

关键词: 原发性肝癌, 乙型肝炎肝硬化, 乙型肝炎相关性肝癌, 乙型肝炎表面抗原

Abstract: Objective To explore the clinical significance of surface antigen of hepatitis B virus quantification in patients with hepatitis B cirrhosis or with liver cirrhosis complicated with hepatocellular carcinoma(HCC) for early diagnosis of HBV related HCC. Methods 54 patients with hepatocellular carcinoma complicated by hepatitis B cirrhosis were enrolled into observation group, as well as 72 patients with simple hepatitis B cirrhosis were enrolled into control group. The serum HBsAg levels and HBV DNA loads were compared between the two groups. Results The serum HBsAg and HBV DNA in observation group were significantly decreased compared with that in control group(P<0.001). Conclusion The serum HBsAg were decreased in the course of Hepatitis B cirrhosis into hepatocellular carcinoma. The quantification of HBsAg was a predictor of hepatocarcinogenesis with clinical significance of early diagnosis.

Key words: Hepatocellular carcinoma(HCC), Hepatitis B cirrhosis , HBV related HCC, Surface antigen of hepatitis B virus(HBsAg )

薛宏丽, 白晶, 单洪, 秦丽莉. HBsAg定量在乙型肝炎相关性肝癌患者中检测的临床意义[J]. 肝脏, 2020, 25(7): 743-745.

XUE Hong-li, BAI Jin, SHAN Hong, QIN Li-li. Clinical significance of surface antigen of hepatitis B virus quantification in patients with hepatitis B cirrhosis related primary liver cancer[J]. Chinese Hepatolgy, 2020, 25(7): 743-745.

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