氩氦刀联合肝动脉栓塞化疗在不可手术的中晚期肝癌患者中的疗效分析

肝脏 ›› 2020, Vol. 25 ›› Issue (9): 919-921.

氩氦刀联合肝动脉栓塞化疗在不可手术的中晚期肝癌患者中的疗效分析

李睿, 史勤生

100029 北京中医药大学第三附属医院针灸微创肿瘤科(李睿);首都医科大学附属北京佑安医院介入科(史勤生)

收稿日期:2020-02-20 出版日期:2020-09-30 发布日期:2020-10-22
基金资助:
北京市科技计划课题(Z161100000516136)

An Analysis on the efficacy of combination therapy with argon-helium knife cryoablation and transcatheter hepatic arterial chemoembolization for unoperable patients with advanced liver cancers

LI Rui¹, SHI Qin-sheng²

1. Department of Acupuncture, Minimally Invasive Oncology, The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100029;
2. Department of Interventional, Beijing You'an Hospital Affiliated to Capital Medical University, Beijing 100069, China

Received:2020-02-20 Online:2020-09-30 Published:2020-10-22

摘要/Abstract

摘要： 目的探讨氩氦刀联合肝动脉栓塞化疗(TACE)在不可手术的中晚期肝癌患者中的疗效。方法选择我院2012年6月—2015年6月144例肝癌患者为研究对象,以随机数表法分为观察组与对照组,均72例。对照组采用TACE治疗,观察组在对照组基础上采用氩氦刀介入治疗。比较两组患者临床疗效、治疗后生存情况和不良反应总发生率。结果观察组总有效率77.78%显著高于对照组54.17%,差异有统计学意义(P<0.05)。两组患者治疗后生存情况采取Log-Rank检验,生存率相当,差异无统计学意义(P>0.05)。观察组不良反应总发生率12.50%与对照组8.33%比较,差异无统计学意义(P>0.05)。结论氩氦刀联合TACE在不可手术的中晚期肝癌患者治疗中,疗效可靠且安全性较高,值得临床应用。

关键词: 氩氦刀, 肝动脉栓塞化疗, 生存率

Abstract: Objective To investigate the efficacy of combination therapy with argon-helium knife cryoablation and transcatheter hepatic arterial chemoembolization (TACE) for upoperable patients with advanced liver cancers. Methods One hundred and forty-four cases of unoperable patients with advanced liver cancers were selected in this study. They were divided into the observation group and the control group by random number table method, with 72 cases in each group. The control group was treated with TACE, and the observation group was treated with argon-helium cryoablation on the basis of TACE. The clinical efficacy, survival rate after treatment and the overall incidence of adverse reactions were compared between these two groups. Results The total effective rate of the observation group was significantly higher than that of the control group (77.78% vs 54.17%, P<0.05). Compared by Log-Rank test the survival rates between these two groups were not significantly different (P>0.05). The total incidence of adverse reactions in the observation group was 12.50%, which has no significant difference when compared with 8.33% in the control group (P>0.05). Conclusion The combination therapy with argon-helium cryoablation and TACE are effective and safety for the treatment of unoperable patients with advanced liver cancers, thus it is worth of clinical application.

Key words: Argon-helium knife cryoablation, Transcatheter hepatic arterial chemoembolization, Unoperable liver cancer

李睿, 史勤生. 氩氦刀联合肝动脉栓塞化疗在不可手术的中晚期肝癌患者中的疗效分析[J]. 肝脏, 2020, 25(9): 919-921.

LI Rui, SHI Qin-sheng. An Analysis on the efficacy of combination therapy with argon-helium knife cryoablation and transcatheter hepatic arterial chemoembolization for unoperable patients with advanced liver cancers[J]. Chinese Hepatolgy, 2020, 25(9): 919-921.

参考文献

[1] 林莲. 原发性肝癌TACE术后患者焦虑抑郁特点及干预研究. 肝脏, 2019,24:720-721.
[2] 魏矿荣. 全球肝癌流行概况. 中国肿瘤, 2015, 24:621-630.
[3] 王维民, 黄延庭. 关于肝功能分级标准的商榷. 中华普通外科杂志, 1998, 13:70-73.
[4] 芮静安. 现代肝癌诊断治疗学. 清华大学出版社, 2004:101-106.
[5] 杨学宁, 吴一龙. 实体瘤治疗疗效评价标准—RECIST. 循证医学, 2004, 4:85-90.
[6] 程玉佩, 张明香. 中医药治疗原发性肝癌研究进展. 辽宁中医药大学学报, 2018,20:167-169.
[7] 相迪, 戴建国. 原发性肝癌的综合治疗研究进展. 山东医药, 2017, 57:111-112.
[8] 程黎, 苟剑林, 刘燕, 等. 经肝动脉化疗栓塞术联合微波消融对中晚期肝癌细胞免疫功能和预后的影响. 中国临床保健杂志, 2016, 19:135-137.
[9] 李洪璐, 段又佳, 陈正光, 等. TACE联合微波消融治疗原发性肝癌特殊部位病灶的跟踪观察. 临床放射学杂志, 2018, 37:1369-1373.
[10] 何志江, 刘云军, 温坚,等. 肝动脉化疗栓塞联合微波消融治疗原发性巨块型肝癌的疗效. 医学临床研究, 2016, 33:1348-1350.
[11] 宗迎迎, 徐浩, 许伟, 等. 经肝动脉化疗栓塞联合经皮微波消融序贯治疗早期肝癌的疗效及预后影响因素. 介入放射学杂志, 2015,24:210-214.
[12] 李景东. 肝动脉栓塞化疗结合氩氦刀治疗中晚期肝癌的临床疗效. 当代医学, 2017, 23:104-106.
[13] 张贺, 乔森. TACE联合其他治疗方式治疗不可切除原发性肝癌的研究进展. 临床医学研究与实践, 2017, 2:194-195.
[14] 倪明立. 肝动脉化疗栓塞联合氩氦刀冷冻消融治疗对不能手术的中晚期肝癌疗效的临床观察. 临床肝胆病杂志, 2015,31:99-102.
[15] 徐稳深. 氩氦刀冷冻消融治疗肝癌的临床疗效与安全性观察. 临床医学工程, 2018, 25:405-406.