关键词: 肝细胞癌, 射频消融, 10年长期有效性

Abstract: Objective To investigate the long-term efficacy of a decade after radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC). Methods Two hundred and ten patients with HCC underwent RFA treatment were enrolled in this study. The patients were followed up for ten to twelve years after surgery, and the treatment efficacy and outcome of RFA were recorded. According to the clinical experience and literature, 12 relevant factors that may affect the therapeutic efficacy of RFA were selected, and the differences in survival curves of each subgroup were analyzed. The factors with differences in survival curves were incorporated into COX regression model to analyze the independent factors affecting the 10-year long-term survival of patients treated with RFA for hepatocellular carcinoma. Results The first complete ablation rate was 89.05% among 210 patients. No serious complications occurred after the operation. Most patients were discharged within 1 week after surgery. At the end of the follow-up, a total of 144 patients died and 32 patients relapsed; Univariate analysis suggested that the tumor number, tumor diameter, safe margin of ablation, whether the tumor is adjacent to a large blood vessel, the Child-Pugh classification, the first ablation effect, PLT, AFP, and BCLC grade were all associated with 10-year survival of HCC patients after RFA (P<0.05); COX multivariate analysis showed that tumor number, tumor diameter, ablation safety margin, and Chind-Pugh classification were independent factors affecting the 10-year survival of patients with hepatocellular carcinoma after RFA. Conclusion RFA has the advantages of minimal invasive and high efficiency in the treatment of hepatocellular carcinoma, while the long term efficacy is affected by the tumor number, tumor size, ablation safety boundary and child Pugh classification of liver function, so the treatment plan should be selected based on the patients' condition.

Key words: Hepatocellular carcinoma, Radiofrequency ablation, Long-term efficacy