以索磷布韦为基础的DAA治疗泛基因型慢性丙型肝炎患者的疗效观察

肝脏 ›› 2021, Vol. 26 ›› Issue (11): 1224-1227.

以索磷布韦为基础的DAA治疗泛基因型慢性丙型肝炎患者的疗效观察

郭峰, 窦婧, 徐强, 王晓波, 马燕, 乐永红, 胡西百合提, 王转国, 王宏峰, 王晓忠

830000 乌鲁木齐新疆维吾尔自治区中医医院肝病科(郭峰,徐强,王晓波,马燕,乐永红,胡西百合提,王转国,王宏峰,王晓忠),新疆医科大学(窦婧)

收稿日期:2020-12-07 出版日期:2021-11-30 发布日期:2021-12-24
通讯作者: 王晓忠,Email:wxz125@sina.com

The efficacy of sofosbuvir-based DAAs treatment on chronic hepatitis C patients with pan-genotypic hepatitis C viral infection

GUO Feng¹, DOU Jing², XU Qiang¹, WANG Xiao-bo¹, MA Yan¹, YUE Yong-hong¹, Huxibaiheti¹, WANG Zhuan-guo¹, WANG Hong-feng¹, WANG Xiao-zhong¹

1. Department of Liver Diseases, Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000, China;
2. Xinjiang Medical University,Urumqi 830000, China

Received:2020-12-07 Online:2021-11-30 Published:2021-12-24
Contact: WANG Xiao-zhong,Email:wxz125@sina.com

摘要/Abstract

摘要： 目的评价以索磷布韦为基础的DAA治疗泛基因型慢性丙型肝炎患者的疗效。方法采用回顾性分析,收集2017年7月至2020年1月在新疆医科大学第四附属医院肝病科诊断为慢性丙型肝炎,并接受以索磷布韦为基础的DAA治疗方案且完成疗程的患者(均使用目前上市的DAA药物),治疗期间均采用高灵敏HCV RNA检测,观察抗病毒治疗的SVR率。结果共纳入患者134例,其中男性72例,女性62例;年龄<60岁95例,年龄≥60岁39例。汉族121例,少数民族13例;初治118例,经治16例;肝硬化59例,非肝硬化75例。基因型:1b型53例,2a型57例,3a型10例,3b型12例,6型1例,混合型(1b,2a)1例。基因1b型:索磷布韦/维帕他韦治疗23例,索磷布韦联合利巴韦林治疗16例,来迪派韦/索磷布韦治疗11例,索磷布韦联合达拉他韦治疗3例,疗程12周。基因2a型:索磷布韦/维帕他韦治疗32例,索磷布韦/维帕他韦片联合利巴韦林治疗5例,索磷布韦联合利巴韦林治疗20例,疗程12周。基因3型:索磷布韦/维帕他韦治疗16例,疗程12周;索磷布韦联合利巴韦林治疗6例,疗程12～24周。基因6型:索磷布韦联合利巴韦林治疗1例,疗程12周。混合型:索磷布韦/维帕他韦片1例,疗程12周。以索磷布韦为基础的DAA治疗慢性丙型病毒性肝炎患者均达到SVR。结论以索磷布韦为基础的DAA治疗泛基因型慢性丙型肝炎患者治愈率高,耐受性好。

关键词: 慢性丙型病毒性肝炎, 泛基因型, 索磷布韦, SVR率

Abstract: Objective To evaluate the efficacy of sofosbuvir-based direct-acting antiviral agents (DAA) treatment on chronic hepatitis C patients with pan-genotypic hepatitis C viral infection. Methods A total of 134 Patients diagnosed with chronic hepatitis C in the Liver Diseases Branch of Fourth Affiliated Hospital of Xinjiang Medical University from July 2017 to January 2020 were collected and retrospectively analyzed. These patients received sofosbuvir-based DAAs and completed the recommended treatment course. They had been tested with highly sensitive hepatitis C RNA quantification method during the treatment to observe the sustained virological response (SVR) rate of antiviral treatment. Results Within the 134 patients, 72 were males and 62 were females; 95 patients were <60 years old, 39 patients were ≥60 years old; 121 patients were Han nationality, 13 patients were ethnic minorities; 118 were treatment naïve patients, 16 patients had previous treatment-experience; 59 patients were cirrhotic and 75 were non-cirrhotic; For the infected HCV genotype (GT): 53 patients were GT 1b, 57 patients were GT 2a, 10 patients were GT 3a, 12 patients were GT 3b, 1 patient was of GT 6, and 1 patient was mixed GTs 1b and 2a. For GT1b, 23 patients were treated with sofosbuvir/velpatasvir,16 patients were treated with sofosbuvir plus ribavirin, 11 patients were treated with ledipasvir/sofosbuvir and 3 patients were treated with sofosbuvir plus daclatasvir for 12 weeks. For GT 2a, 32 patients were treated with sofosbuvir/velpatasvir, 5 patients were treated with sofosbuvir/velpatasvir plus ribavirin and 20 patients were treated with sofosbuvir plus ribavirin for 12 weeks. For GT 3, 16 patients were treated with sofosbuvir/velpatasvir for 12 weeks; 6 patients were treated with sofosbuvir plus ribavirins for 12-24 weeks. For GT 6: 1 patient was treated with sofosbuvir plus ribavirin tablets for 12 weeks. For mixed GTs (1b, 2a): 1 patient was treated with sofosbuvir/velpatasvir for 12 weeks. Sofosbuvir-based DAAs treatment of all patients with chronic hepatitis C reached SVR. Conclusion The Sofosbuvir-based DAAs treatment has a high overall SVR and well tolerance in chronic hepatitis C patients with pan-genotypic HCV infection.

Key words: chronic hepatitis C, hepatitis C viral infection, pan-genotype, sofosbuvir, sustained virological response rate

郭峰, 窦婧, 徐强, 王晓波, 马燕, 乐永红, 胡西百合提, 王转国, 王宏峰, 王晓忠. 以索磷布韦为基础的DAA治疗泛基因型慢性丙型肝炎患者的疗效观察[J]. 肝脏, 2021, 26(11): 1224-1227.

GUO Feng, DOU Jing, XU Qiang, WANG Xiao-bo, MA Yan, YUE Yong-hong, Huxibaiheti, WANG Zhuan-guo, WANG Hong-feng, WANG Xiao-zhong. The efficacy of sofosbuvir-based DAAs treatment on chronic hepatitis C patients with pan-genotypic hepatitis C viral infection[J]. Chinese Hepatolgy, 2021, 26(11): 1224-1227.

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