加用N-乙酰半胱氨酸对行TACE的HCC患者术后的影响

肝脏 ›› 2021, Vol. 26 ›› Issue (12): 1336-1338.

加用N-乙酰半胱氨酸对行TACE的HCC患者术后的影响

徐晓美, 鲁小敏, 沈预程, 钱俐

226600 江苏南通大学附属海安医院肿瘤科(徐晓美,鲁小敏,沈预程);南通大学附属医院肿瘤科(钱俐)

收稿日期:2021-01-28 发布日期:2022-01-13
通讯作者: 徐晓美,Email:1098968326@qq.com
基金资助:
南通市2017年度市级科技计划项目(MS12017017)

Influence of N-acetylcysteine on hepatocellular carcinoma patients undergoing TACE

XU Xiao-mei¹, LU Xiao-min¹, SHEN Yu-cheng¹, QIAN Li²

1. Department of Oncology, Hai'an Hospital Affiliated to Nantong University, Jiangsu 226600,China;
2. Department of Oncology, Affiliated Hospital of Nantong University, Jiangsu 226001, China

Received:2021-01-28 Published:2022-01-13
Contact: XU Xiao-mei, Email: 1098968326@qq.com

摘要/Abstract

摘要： 目的探讨对行肝动脉化疗栓塞术(TACE)的原发性肝癌(HCC)患者采用N-乙酰半胱氨酸(NAC)治疗的效果。方法将72例行TACE的HCC患者分成两组,在常规措施的基础上,对照组给予甘草酸二铵注射液治疗,观察组加用NAC治疗,观察患者氧化应激、T淋巴亚群和肝功能指标的变化。结果治疗4周后,观察组的血清超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)、CD3⁺、CD4⁺和CD4⁺/CD8⁺水平显著升高,丙二醛(MDA)和CD8⁺水平显著降低(P<0.05);观察组ALT和TBil水平显著低于对照组(P<0.05),两组ALB和FIB水平无差异(P＞0.05)。两组不良反应比较无显著差异(P>0.05)。结论 NAC能抑制TACE患者的氧化应激水平,调节机体的细胞免疫功能,改善肝功能,安全性较高。

关键词: 肝动脉化疗栓塞术, N-乙酰半胱氨酸, 氧化应激, 免疫功能, 肝功能

Abstract: Objective To investigate the therapeutic effect of N-acetylcysteine (NAC) in hepatocellular carcinoma(HCC) patients undergoing transcatheter arterial chemoembolization (TACE). Methods Seventy-two HCC patients undergoing TACE were divided into 2 groups. On the basis of conventional therapy, the control group was treated with diammonium glycyrrhizinate intravenous infusion, and the observation group was treated with NAC. The changes of oxidative stress, T lymphatic subsets and liver function indexes were recorded. Results After 4-week treatment, the levels of serum superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in observation group were significantly increased, while the levels of malondialdehyde (MDA) and CD8⁺ in observation group were significantly decreased (P<0.05). The levels of alanine aminotransferase (ALT) and total bilirubin (TBIL) in observation group were significantly lower than those in control group (P<0.05). There was no significant difference in the levels of albumin (ALB) and fibrinogen (FIB) between the 2 groups (P>0.05). There was no significant difference in adverse drug reactions (ADR) between the 2 groups (P>0.05). Conclusion NAC can inhibit the oxidative stress level, regulate cellular immune function and improve the liver function of HCC patients undergoing TACE, and it has high safety.

Key words: Transcatheter arterial chemoembolization, N-acetylcysteine, Oxidative stress, Immune function, Liver function

徐晓美, 鲁小敏, 沈预程, 钱俐. 加用N-乙酰半胱氨酸对行TACE的HCC患者术后的影响[J]. 肝脏, 2021, 26(12): 1336-1338.

XU Xiao-mei, LU Xiao-min, SHEN Yu-cheng, QIAN Li. Influence of N-acetylcysteine on hepatocellular carcinoma patients undergoing TACE[J]. Chinese Hepatolgy, 2021, 26(12): 1336-1338.

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