肝脏 ›› 2021, Vol. 26 ›› Issue (3): 305-308.

• 其他肝病 • 上一篇    下一篇

磁共振波谱成像检测肝内脂肪浸润水平诊断非酒精性脂肪肝的价值

刘小玲, 阮君, 朱敬松   

  1. 450014 河南 郑州大学第二附属医院放射科
  • 收稿日期:2020-05-04 发布日期:2021-04-21
  • 基金资助:
    河南省科技攻关计划项目(201701179)

Value analysis of intrahepatic fat infiltration level detected by magnetic resonance spectroscopy in diagnosis of nonalcoholic fatty liver disease

LIU Xiao-ling, RUAN Jun, ZHU Jing-song   

  1. Radiology Department, the Second Affiliated Hospital of Zhengzhou University, Henan 450014, China
  • Received:2020-05-04 Published:2021-04-21

摘要: 目的 探讨磁共振波谱成像(MRS)检测肝内脂肪浸润值(FF值)诊断非酒精性脂肪性肝病(NAFLD)的价值。 方法 2016年12月至2019年12月郑州大学第二附属医院收治的NAFLD患者138例,均接受常规CT检查。所有患者均于CT检查后3 d内行MRS检查,获取FF值。分析不同程度的NAFLD患者MRS波谱谱线,比较不同程度的NAFLD患者FF值变化情况,并评价FF值与NAFLD严重程度及CT肝/脾的相关性。 结果 138例NAFLD患者均顺利完成MRS检测。所有患者MRS谱线water峰和lip峰均呈现双峰表现,其余物质与直线接近;其中轻度和中度NAFLD患者均呈前高后低双峰表现,即高water峰、低lip峰,而重度NAFLD患者呈前低后高双峰表现,即低water峰、高lip峰。轻度NAFLD患者FF值显著低于中度、重度NAFLD患者(P<0.05),中度NAFLD患者FF值显著低于重度NAFLD患者(P<0.05)。FF值与NAFLD严重程度呈高度正相关(秩相关系数rS=0.838,P<0.001)。NAFLD患者FF值与CT肝/脾呈负相关 (r=-0.920,P<0.001) 。 结论 利用MRS检测FF值,对评价NAFLD严重程度具有重要意义,临床应广泛推广。

关键词: 磁共振波谱成像, 肝内脂肪浸润, 非酒精性脂肪性肝病

Abstract: Objective To explore the value of MR spectroscopy (MRS) in detecting intrahepatic fat infiltration (FF) in the diagnosis of nonalcoholic fatty liver disease (NAFLD). Methods Between December 2016 to December 2019, 138 patients with NAFLD in our hospital received routine CT examination. All patients underwent MRS examination within 3 days after CT examination to obtain FF value. MRS spectrum lines of NAFLD patients with different degrees were analyzed, FF values of NAFLD patients with different degrees were compared, and the correlation between FF values and NAFLD severity and CTliver/spleen was evaluated. Results 138 patients with NAFLD successfully completed MRS examination.The water peak and lip peak of MRS spectrum in all patients showed double peaks, and the other substances were close to the straight line;Among them, patients with mild and moderate NAFLD showed high anteropotential and low anteropotential, namely high water peak and low lip peak, while patients with severe NAFLD showed low anteropotential and high lip peak, namely low water peak and high lip peak.The FF value of patients with mild NAFLD was significantly lower than that of patients with moderate and severe NAFLD (P<0.05), and the FF value of patients with moderate NAFLD was significantly lower than that of patients with severe NAFLD (P<0.05).FF value was highly positively correlated with NAFLD severity (rank correlation coefficient rS=0.838, P<0.001).FF value in NAFLD patients was negatively correlated with CTliver/spleen (r=-0.920, P<0.001). Conclusion The detection of FF by MRS was of great significance to evaluate the severity of NAFLD and should be widely used in clinical practice.

Key words: Magnetic resonance spectroscopy, Intrahepatic fat infiltration, Nonalcoholic fatty liver disease