关键词: CT灌注成像, 血吸虫性肝硬化, 预后

Abstract: Objective To study on the value of computed tomography (CT) perfusion parameters in quantitatively predicting the prognosis of schistosomal cirrhotic patients. Methods Eighty-four patients with schistosomal cirrhosis who had underwent 64-slice spiral CT perfusion scanning of liver were enrolled in this study. According to patients' prognosis they were divided into a death group (30 cases) and a survival group (54 cases), The CT liver perfusion imaging parameters, hepatic blood volume (BV), hepatic blood flow (BF), average contrast agent through time (determined by MTT) and hepatic arterial fraction (HAF), hepatic artery perfusion (HAP) of these two groups of patients were compared. Receiver-operating characteristic (ROC) curve was applied to evaluate the predictive efficacy of these parameters for the prognosis of the schistosomal cirrhotic patients. Results The BV and BF of the death group were significantly lower than those of the survival group (P<0.05), and the MTT, HAF, and HAP were significantly higher than those of the survival group (P<0.05). CT perfusion imaging parameters BV, BF, MTT, HAF, HAP had a certain predictive efficacy on the prognosis of patients with schistosomal cirrhosis, the area under the curve was 0.660, 0.637, 0.765, 0.674, 0.721, respectively. Conclusion CT liver perfusion imaging parameters BV, BF, MTT, HAF, HAP have important predictive value for the prognosis of patients with schistosomal cirrhosis, which should be taken adequate clinical attention.

Key words: CT perfusion imaging, Schistosomal cirrhosis, Prognosis