186例肝内胆管癌的预后影响因素分析

肝脏 ›› 2022, Vol. 27 ›› Issue (2): 182-184.

186例肝内胆管癌的预后影响因素分析

苗慧, 万旭英

201805 上海海军军医大学第三附属医院中西医结合科

收稿日期:2021-04-30 出版日期:2022-02-28 发布日期:2022-04-19
通讯作者: 万旭英,Email:wanxuying@126.com
基金资助:
上海市卫生和计划生育委员会中医优势病种培育项目(zybz-2017030)

An analysis of the prognostic influencing factors of intrahepatic cholangiocarcinoma

MIAO Hui, WAN Xu-ying

Department of Integrative Medicine, the Third Affiliated Hospital of Naval Medical University,Shanghai 201805,China

Received:2021-04-30 Online:2022-02-28 Published:2022-04-19
Contact: WAN Xu-ying, Email: wanxuying@126.com

摘要/Abstract

摘要： 目的探讨肝内胆管癌预后的影响因素。方法收集2015年1月至2020年1月海军军医大学第三附属医院安亭院区经病理诊断为肝内胆管癌的186例患者资料,电话随访所有患者生存状况,分析影响总体生存期的因素。采用Kaplan-Mier分析总体生存期及疾病无进展期,Cox回归分析预后影响因素。结果肝内胆管癌患者的1年、3年、5年生存率分别为80.6%,32.2%,17.4%;无进展生存率分别为57.6%,22.9%,13.0%。多因素分析结果显示TNM分期Ⅳ期(HR:2.77;95%CI :1.43~5.36;P=0.002)、根治性手术(HR:0.47; 95%CI :0.26~0.84;P=0.012)、淋巴结转移(HR:2.11;95%CI :1.33~3.35;P=0.001)、血管侵犯(HR:1.74;95%CI :1.04~2.89;P=0.033)是影响总体生存的独立影响因素。结论 TNM分期Ⅳ期、根治性手术、淋巴结转移、血管侵犯是影响总体生存的独立影响因素。

关键词: 肝内胆管癌, 预后, 影响因素

Abstract: Objective To further clarify the prognostic factors of intrahepatic cholangiocarcinoma. Methods The data of 186 patients with intrahepatic cholangiocarcinoma who were admitted from January 2015 to January 2020 were retrospectively collected. The survival status of all patients was followed up by telephone. Multivariate analysis was used to analyze the influencing factors of overall survival. Kaplan-Mier analysis was used to describe the overall survival and disease progression free period. Cox regression model was used to analyze the prognostic factors. Results The 1-, 3-, and 5-year survival rates were 80.6%, 32.2%, and 17.4%, respectively; the 1-, 3-, and 5-year progression free survival rates were 57.6%, 22.9%, and 13.0%, respectively. Multivariate analysis showed that TNM stage IV (HR: 2.77; 95%CI: 1.43-5.36; P=0.002), radical surgery (HR: 0.47; 95%CI: 0.26-0.84; P=0.012), lymph node metastasis (HR: 2.11; 95%CI: 1.33-3.35; P=0.001), vascular invasion (HR: 1.74; 95%CI: 1.04-2.89; P=0.033) were independent factors affecting overall survival. Conclusion TNM stage IV, radical operation, lymph node metastasis and vascular invasion are independent factors affecting the overall survival of patients with intrahepatic cholangiocarcinoma.

Key words: Intrahepatic cholangiocarcinoma, Prognosis, Factors

苗慧, 万旭英. 186例肝内胆管癌的预后影响因素分析[J]. 肝脏, 2022, 27(2): 182-184.

MIAO Hui, WAN Xu-ying. An analysis of the prognostic influencing factors of intrahepatic cholangiocarcinoma[J]. Chinese Hepatolgy, 2022, 27(2): 182-184.

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