急性戊型肝炎临床特征及危险因素分析

肝脏 ›› 2022, Vol. 27 ›› Issue (2): 218-221.

急性戊型肝炎临床特征及危险因素分析

刘玉, 梅雪, 张宇一, 邹颖, 郭红英, 袁伟, 王介非, 钱志平, 张正国

201508 上海市(复旦大学附属)公共卫生临床中心

收稿日期:2021-04-13 出版日期:2022-02-28 发布日期:2022-04-19
通讯作者: 张正国,Email:zhangzhengguo@shphc.org.cn
基金资助:
国家自然科学面上项目基金(81874436);申康三年行动计划重大临床研究项目(SHDC2020CR1037B-004);国家“十三五”科技重大专项(2018ZX10725506-002)

Clinical features and risk factors of acute hepatitis E

LIU Yu, MEI Xue, ZHANG Yu-yi, ZOU Ying, GUO Hong-ying, YUAN Wei, WANG Jie-fei, QIAN Zhi-ping, ZHANG Zheng-guo

Department of Liver Intensive Care Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China

Received:2021-04-13 Online:2022-02-28 Published:2022-04-19
Contact: ZHANG Zheng-guo, Email: zhangzhengguo@shphc.org.cn

摘要/Abstract

摘要： 目的分析急性戊型肝炎的临床特征和危险因素。方法收集2018年1月1日至2020年3月26日上海市公共卫生临床中心收治确诊为急性戊型肝炎的179例患者的临床资料,总结其临床特征。结果年龄＜60岁为91例,≥60岁为88例;男性129例,女性50例;未合并基础肝病142例,合并基础肝病37例;HBV、HEV重叠感染20例,HEV单纯感染157例;158例好转,21例无效。与年龄＜60岁患者相比,≥60岁患者的ALT和TBil更高,GGT和Alb更低,住院时间更长;与女性患者相比,男性患者的TBil、PT、肝脏弹性值更高,住院时间更长;与未合并基础肝病患者相比,合并基础肝病患者住院时间更长;与HEV单感染患者,乙戊重叠感染患者住院时间更长;与好转组比较,无效组男性占比多,发生肝衰竭比例高,AST、TBil、PT、肝脏弹性值均偏高,GGT、Alb均偏低。TBil(P=0.001)、Alb(P=0.041)、PT(P=0.009)是影响预后的危险因素。结论 AHE患者男性占比高,老年、男性的病情相对严重,老年、男性、合并基础肝病及HBV、HEV重叠感染患者的住院时间相对更长,TBil、Alb、PT是影响预后的危险因素。

关键词: 急性戊型肝炎, 临床特征, 戊型肝炎病毒

Abstract: Objective To analyze the clinical characteristics and risk factors of acute hepatitis E. Methods Clinical data of 179 patients diagnosed with acute hepatitis E (AHE) in Shanghai Public Health Clinical Center were collected and their clinical characteristics were summarized. Results 91 of them were over 60 years old, 129 were males, 37 cases were complicated with underlying basic liver diseases, 20 cases were HBV and HEV combined infection and 157 cases with only HEV infection, 158 cases were improved. Compared with patients under 60 years old, those patients over 60 years old showed significantly higher ALT and TBIL levels, lower GGT and Alb levels and longer hospital stay. Compared with females, males showed significantly higher TBil, PT and the liver stiffness value levels, longer hospital stay. Compared with those patients without basic liver diseases, those patients with basic liver diseases showed significantly longer hospital stay. Compared with only HEV infection, those patients with HBV and HEV combined infection showed significantly longer hospital stay. Compared with those improved patients, invalid group had more males, more occurred liver failure, with higher AST, TBil, PT and the liver stiffness value levels, lower GGT and Alb levels. TBil (P=0.001), ALB (P=0.041), PT (P=0.009) were risk factors affecting the prognosis. Conclusion In patients with AHE, there is a higher proportion of males, elderly and males are relatively more serious, elderly, males, combined basic liver disease, HBV and HEV combined infection have relatively longer hospital stay. TBil, Alb, PT are risk factors affecting the prognosis.

Key words: Acute hepatitis E, Clinical analysis, Hepatitis E virus

刘玉, 梅雪, 张宇一, 邹颖, 郭红英, 袁伟, 王介非, 钱志平, 张正国. 急性戊型肝炎临床特征及危险因素分析[J]. 肝脏, 2022, 27(2): 218-221.

LIU Yu, MEI Xue, ZHANG Yu-yi, ZOU Ying, GUO Hong-ying, YUAN Wei, WANG Jie-fei, QIAN Zhi-ping, ZHANG Zheng-guo. Clinical features and risk factors of acute hepatitis E[J]. Chinese Hepatolgy, 2022, 27(2): 218-221.

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