诱导多能干细胞向肝脏细胞分化的研究进展

摘要/Abstract

摘要： 肝脏是人体最大的实质性器官,是不可或缺的“化工厂”。肝细胞的非正常死亡影响肝脏功能进而影响人体物质代谢,终末期肝病的高死亡率尚未得到有效解决。人类诱导多能干细胞提供了一种潜在的、取之不尽的自体干细胞来源,在不同生长因子和小分子物质诱导下逐步分化成包含肝细胞样细胞在内的多种组织细胞。近年来,通过模拟肝脏发育的三维环境,干细胞分化的肝细胞样细胞在表型和功能表达上更接近成人肝细胞,为肝脏疾病治疗研究和药物开发提供广阔的平台。本文将阐述人诱导多能干细胞向肝脏细胞分化的新技术及相关应用前景。

关键词: 诱导多能干细胞, 分化, 肝脏细胞, 细胞治疗, 疾病建模, 药物研发

陈金梅, 姚婷, 陈小华. 诱导多能干细胞向肝脏细胞分化的研究进展[J]. 肝脏, 2022, 27(3): 367-369.

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