[1] Squadroni M, Tondulli L, Gatta G, et al. Cholangiocarcinoma. Crit Rev Oncol Hematol,2017,116:11-31. [2] Le Faouder J, Gigante E, Léger T, et al. Proteomic landscape of cholangiocarcinomas reveals three different subgroups according to their localization and the aspect of non-tumor liver. Proteomics Clin Appl,2019,13:e1800128. [3] Tyson GL, El-Serag HB. Risk factors for cholangiocarcinoma. Hepatology,2011,54:173-184. [4] Cillo U, Fondevila C, Donadon M, et al. Surgery for cholangiocarcinoma. Liver Int,2019,39 Suppl 1:143-155. [5] Ong CK, Subimerb C, Pairojkul C, et al. Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet,2012,44:690-693. [6] Talabnin K, Talabnin C, Khiaowichit J, et al. High expression of tissue O-linked glycans is associated with a malignant phenotype of cholangiocarcinoma. J Int Med Res,2021,49:300060520976864. [7] Talabnin K, Talabnin C, Kumagai T, et al. Ganglioside GM2: a potential biomarker for cholangiocarcinoma. J Int Med Res,2020,48:300060520903216. [8] Tsujie M, Iwai T, Kubo S, et al. Fibroblast growth factor receptor 2 (FGFR2) fusions in Japanese patients with intrahepatic cholangiocarcinoma. Jpn J Clin Oncol. 2021,51:911-917. [9] Gong X, Zou L, Wang M, et al. Gramicidin inhibits cholangiocarcinoma cell growth by suppressing EGR4. Artif Cells Nanomed Biotechnol,2020,48:53-59. [10] Pierson DL, Brien JM. Human carbamylphosphate synthetase I. Stabilization, purification, and partial characterization of the enzyme from human liver. J Biol Chem, 1980,255:7891-7895. [11] Huang X, Raushel FM. Restricted passage of reaction intermediates through the ammonia tunnel of carbamoyl phosphate synthetase. J Biol Chem,2000,275:26233-26240. [12] Häberle J, Schmidt E, Pauli S, et al. Gene structure of human carbamylphosphate synthetase 1 and novel mutations in patients with neonatal onset. Hum Mutat, 2003,21:444. [13] Moreno-Morcillo M, Grande-García A, et al. Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis. Structure,2017,25:912-923. [14] Zhang W, Dong Z, Xu M, et al. SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α. Mol Metab, 2020,32:85-96. [15] Summar ML, Koelker S, Freedenberg D, et al. The incidence of urea cycle disorders. Mol Genet Metab,2013,110:179-180. [16] Butler SL, Dong H, Cardona D, et al. The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Lab Invest,2008,88:78-88. [17] Liu TH, Li DC, Gu CF, et al. Carbamyl phosphate synthetase I. A novel marker for gastric carcinoma. Chin Med J (Engl),1989,102:630-638. [18] Çeliktas M, Tanaka I, Tripathi SC, et al. Role of CPS1 in cell growth, metabolism and prognosis in LKB1-inactivated lung adenocarcinoma. J Natl Cancer Inst,2017,109:1-9. [19] Cardona DM, Zhang X, Liu C. Loss of carbamoyl phosphate synthetase I in small-intestinal adenocarcinoma. Am J Clin Pathol,2009,132:877-882. [20] Butler SL, Dong H, Cardona D, et al. The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Lab Invest,2008,88:78-88. [21] Kim J, Hu Z, Cai L, et al. CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells. Nature,2017,546:168-172. [22] Liu X, Zhang X, et al. Caspase recruitment domain family member 10 regulates carbamoyl phosphate synthase 1 and promotes cancer growth in bladder cancer cells. J Cell Mol Med,2019,23:8128-8138. [23] Rolfe A, Yao S, Nguyen TV, et al. Discovery of 2,6-dimethylpiperazines as allosteric Inhibitors of CPS1. ACS Med Chem Lett,2020,11:1305-1309. [24] Wang TH, Yu CC, Lin YS, et al. Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition. Oncotarget,2016,7:43588-43603. [25] Wang YS, Ma LN, et al. Long non-coding RNA CPS1-IT1 is a positive prognostic factor and inhibits epithelial ovarian cancer tumorigenesis. Eur Rev Med Pharmacol Sci, 2017,21:3169-3175. [26] Xiaoguang Z, Meirong L, et al. Long noncoding RNA CPS1-IT1 suppresses cell proliferation and metastasis in human lung cancer. Oncol Res,2017,25:373-380. [27] Zhang W, Yuan W, et al. LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α. Biochimie,2018,144:21-27. [28] Zhou X, Rao Y, Sun Q, et al. Long noncoding RNA CPS1-IT1 suppresses melanoma cell metastasis through inhibiting Cyr61 via competitively binding to BRG1. J Cell Physiol,2019,234:22017-22027. [29] Ma SL, Li AJ, Hu ZY, et al. Coexpression of the carbamoylphosphate synthase 1 gene and its long noncoding RNA correlates with poor prognosis of patients with intrahepatic cholangiocarcinoma. Mol Med Rep,2015,12:7915-7926. [30] Shi J, Li X, Zhang F, et al. The Plasma LncRNA Acting as Fingerprint in Hilar Cholangiocarcinoma. Cell Physiol Biochem,2018,49:1694-1702. |