[1] 延国威.和血柔肝方干预四氯化碳肝纤维化大鼠的实验研究.新疆医科大学,2020. [2] 谢爱泽,吕超,石清兰,等.中医药防治肝纤维化机制的研究进展.中国医药导报,2020,17(17):34-37. [3] Al Mamun A,Wu YQ,Jia C,et al.Role of pyroptosis in liver diseases.Int Immunopharmacol,2020,84:106489 [4] Schwabe RF, Luedde T.Apoptosis and necroptosis in the liver: a matter of life and death.Nat Rev Gastroenterol Hepatol,2018,15(12):738-752. [5] Kashyap D,Garg VK,Goel N.Intrinsic and extrinsic pathways of apoptosis: role in cancer development and prognosis. Adv Protein Chem Struct Biol,2021,125:73-120. [6] Bedoui S,Herold MJ,Strasser A.Emerging connectivity of programmed cell death pathways and its physiological implications.Nat Rev Mol Cell Biol, 2020,21(11):678-695. [7] Yuan Y,Zhao SW,Wen SQ,et al.Alpha-lipoic acid attenuates cadmium- and lead-induced neurotoxicity by inhibiting both endoplasmic-reticulum stress and activation of fas/fasl and mitochondrial apoptotic pathways in rat cerebral cortex. Neurotox Res,2021,39(4):1103-1115. [8] Yuan X,Gajan A,Chu Q,et al.Developing TRAIL/TRAIL death receptor-based cancer therapies.Cancer Metastasis Rev,2018,37(4):733-748. [9] Kashyap D,Garg VK,Goel N.Intrinsic and extrinsic pathways of apoptosis: role in cancer development and prognosis.Adv Protein Chem Struct Biol.2021,125:73-120. [10] Singh D,Tewari M,Singh S,et al.Revisiting the role of TRAIL/TRAIL-R in cancer biology and therapy.Future Oncol,2021,17(5):581-596. [11] Grynberg K,Ma FY,Nikolic-Paterson DJ.The JNK signaling pathway in renal fibrosis. Front Physiol,2017,24(8):829. [12] Novo N,Ferreira P,Medina M.The apoptosis-inducing factor family: moonlighting proteins in the crosstalk between mitochondria and nuclei. IUBMB Life,2021,73(3):568-581. [13] 崔兴,孙润洁,王庆松.桂枝茯苓胶囊通过线粒体途径对骨髓瘤细胞凋亡的影响.中华中医药杂志,2022,37(3):1395-1400. [14] 冯晓雨.Bcl-2/VDAC1介导的线粒体凋亡途径在牛磺酸抗铁过载所致肝损伤中的作用.南昌大学,2022. [15] 王蕴婷,郑晓雅,陈月,等.生长激素受体敲低状态下棕榈酸通过线粒体途径加重肝细胞凋亡.第三军医大学学报,2021,43(21):2366-2374. [16] 黄津,邓凯翔,黄美珍,等.The pharmacological mechanism underlying the apoptosis of human hepatic stellate cells LX-2 induced by NF-κB inhibitor PDTC.Journal of Chinese Pharmaceutical Sciences,2022,31(9):665-676. [17] Martí-Rodrigo A,Alegre F,Moragrega ÁB,et al.Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells. Gut, 2020,69(5):920-932. [18] Roehlen N,Crouchet E,Baumert TF.Liver fibrosis:mechanistic concepts and therapeutic perspectives.Cells,2020,9(4):875. [19] 龙富立,林镛,颜耿杰,等.解毒化瘀颗粒对肝衰竭大鼠肝细胞凋亡的影响与机制研究.时珍国医国药,2022,33(7):1545-1548. [20] 潘留兰,贾胜男,金珍婧,等.DcR3对肝纤维化动物模型的影响.中国免疫学杂志,2016,32(11):1589-1592. [21] Tan S,Liu X,Chen L,et al.Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis.Cell Death Dis, 2021,12(5):474. [22] 刘伟,荆振唐,吴淑香,等. PI3K/AKT抑制剂促进死亡受体介导的肝细胞凋亡及肝损伤.中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议摘要集,2018:113-114. [23] Yang L,Fu WL,Zhu Y,et al.Tβ4 suppresses lincRNA-p21-mediated hepatic apoptosis and fibrosis by inhibiting PI3K-AKT-NF-κB pathway.Gene,2020,758:144946. [24] Loomba R,Lawitz E,Mantry PS, et al. The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: a randomized, phase 2 trial.Hepatology,2018,67(2):549-559. [25] 黄家明.水飞蓟宾通过Fas/FasL信号通路促进肝星状细胞凋亡.九江学院学报(自然科学版),2022,37(3):97-99. [26] 刘欣灵,梁仁久,张晓梅,等.中医药调节信号通路抗肝纤维化的研究进展.环球中医药,2022,15(10):1759-1764. [27] 杨柳,张景允,韩萧萧,等.含氧化苦参碱大鼠血清通过阻断PI3K/AKT通路抑制砷对LX2人肝星状细胞增殖活化的刺激作用.细胞与分子免疫学杂志,2022,38(7):598-604. [28] 罗晓旭. PI3K/Akt信号通路与肝星状细胞活化的关系及其在放射性肝纤维化中的作用.新疆医科大学,2016. [29] Wang Y,Jiang XY,Liu L,et al.Phosphatidylinositol 3-kinase/Akt pathway regulates hepatic stellate cell apoptosis.World J Gastroenterol,2008,14(33):5186-5191. [30] Chen Q,Chen L,Wu X, et al.Dihydroartemisinin prevents liver fibrosis in bile duct ligated rats by inducing hepatic stellate cell apoptosis through modulating the PI3K/Akt pathway.IUBMB Life,2016,68(3):220-231. [31] 郑洋,邓青梅,赵铁建,等.基于PI3K/AKT/mTOR信号通路探讨莪术醇抗肝纤维化的分子机制.中药药理与临床,2021,37(4):36-40. |