肝纤维化进程中巨噬细胞异质性对肝星状细胞命运的影响

摘要/Abstract

摘要： 肝纤维化(HF)是肝脏受到各类慢性损伤后产生的以细胞外基质过度沉积和异常分布为特征的可逆性病理修复反应。肝星状细胞(HSC)的活化是HF发生和发展过程中的核心环节。巨噬细胞是肝脏中最大的固有免疫细胞群,具有高度的异质性,可通过各种信号调节HSC的活化与清除。研究巨噬细胞对HSC表型转换的重要调控作用,有助于我们了解肝脏免疫微环境对HF演化方向的影响,以及从更广阔的视角中探寻抗HF治疗的新靶点。

关键词: 肝纤维化, 巨噬细胞, 异质性, 肝星状细胞

曹越, 邹燕婷, 宁柳心, 徐蓓莉, 张顺财, 蔡瑜. 肝纤维化进程中巨噬细胞异质性对肝星状细胞命运的影响[J]. 肝脏, 2023, 28(11): 1375-1379.

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