TLR4/MyD88/NF-κB信号通路调控肝星状细胞活化及其临床意义

摘要/Abstract

摘要： 各种肝病在演变过程中会经历肝纤维化,严重者会发展为肝硬化。肝纤维化是多种肝病演变过程中必不可少的病理生理过程,肝纤维化的中心环节是肝星状细胞(hepaticstellatecell,HSC)的活化。肝星状细胞是肌成纤维细胞的主要来源,肌成纤维细胞产生大量的细胞基质,当肝脏实质内细胞外基质合成降解失衡时,会导致肝纤维化的发生。因此,肝星状细胞成为抗纤维化治疗的潜在靶点。充分认识HSCs活化所涉及的分子特征和信号通路,有助于更深层次地了解肝纤维化的发病机制。肝星状细胞(HSCs)的活化受到多种信号通路及其他机制调节,目前TLR4/NF-κB信号通路在HSCs活化过程中的作用研究已经受到广泛关注。本文主要论述TLR4/NF-κB信号通路对肝星状细胞活化的影响及对于TLR4/NF-κB信号通路在肝纤维化防治中的策略。

王志会, 周石. TLR4/MyD88/NF-κB信号通路调控肝星状细胞活化及其临床意义[J]. 肝脏, 2023, 28(4): 493-495.

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