转铁蛋白受体-2在铁稳态中的作用研究进展

肝脏 ›› 2023, Vol. 28 ›› Issue (5): 604-606.

转铁蛋白受体-2在铁稳态中的作用研究进展

谢超, 王晓凡, 丛敏

100050 北京首都医科大学附属北京友谊医院肝病中心(肝硬化转化医学北京市重点实验室暨国家消化系统疾病临床医学研究中心)

收稿日期:2022-07-19 出版日期:2023-05-31 发布日期:2023-08-29
通讯作者: 丛敏,Email:maomao0623@sina.com
基金资助:
国家自然科学基金(82170614);王宝恩肝纤维化基金(CFHPC 2021042)

Received:2022-07-19 Online:2023-05-31 Published:2023-08-29

摘要/Abstract

摘要： 铁是人体内非常重要的元素,不仅参与细胞构成,还广泛参与重要的生命代谢过程。体内铁稳态的维持对正常机体生长发育和健康发挥着重要作用。铁调素(hepcidin)是维持铁稳态的重要分子,hepcidin水平受许多因素的调节,近年来有研究发现转铁蛋白受体-2(transferrin receptor 2,TFR2)参与了多条hepcidin调节通路,进而调节全身铁代谢。本文就TFR2在铁稳态中的作用相关研究进展作一综述。

谢超, 王晓凡, 丛敏. 转铁蛋白受体-2在铁稳态中的作用研究进展[J]. 肝脏, 2023, 28(5): 604-606.

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