非酒精性脂肪性肝病相关肝细胞癌的防治策略研究进展

摘要/Abstract

摘要： 肝细胞癌(HCC)是全球最常见的恶性肿瘤之一,具有极高的发病率和死亡率。近年来,随着肥胖和糖尿病的流行,非酒精性脂肪性肝病(NAFLD)相关HCC患者日益增多。NAFLD发展至HCC的过程受到糖尿病、肥胖、种族和遗传多态性等多种因素的影响。大部分NAFLD患者在肝硬化基础上发展成HCC,但约有1/3的NAFLD相关HCC患者并未出现肝硬化,这也对NAFLD相关HCC的早期筛查和干预提出重大挑战。本文旨在总结NAFLD相关HCC发生发展的危险因素、临床特征以及防治策略等方面的研究进展,旨在为优化NAFLD相关HCC诊疗策略提供新思路,从而促进相关人群的早诊早治。

关键词: 非酒精性脂肪性肝病, 肝细胞癌, 危险因素, 风险预测模型, 防治策略

陈倩倩, 杨玥, 倪文婧, 芮法娟, 施军平, 李婕. 非酒精性脂肪性肝病相关肝细胞癌的防治策略研究进展[J]. 肝脏, 2023, 28(6): 639-643.

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