超声内镜引导下穿刺抽吸联合硬化剂注射术治疗肝囊肿的疗效

肝脏 ›› 2023, Vol. 28 ›› Issue (8): 983-986.

超声内镜引导下穿刺抽吸联合硬化剂注射术治疗肝囊肿的疗效

武建, 王连才, 王亚峰, 杜长顺, 肖建安

455000 河南安阳市第三人民医院普外科(武建);河南省人民医院肝胆胰腺外科(王连才,王亚峰);安阳市人民医院普外科(杜长顺);河南科技大学第四附属医院普外科(肖建安)

收稿日期:2022-09-29 出版日期:2023-08-31 发布日期:2023-09-21
基金资助:
2019年河南省医学科技攻关计划联合共建项目(LHGJ20190599)

Effects of endoscopic ultrasound-guided percutaneous aspiration sclerotherapy on serum inflammatory factors in patients with hepatic cysts

WU Jian¹, WANG Lian-cai², WANG Ya-feng², DU Chang-shun³, XIAO Jian-an⁴

1. Department of General Surgery, Anyang Third People's Hospital, Henan 455000, China;
2. Department of Hepatobiliary Pancreatic Surgery,Henan Provincial People's Hospital, Zhengzhou,450000, China;
3. Department of General Surgery, Anyang People's Hospital,Henan 455000, China;
4. Department of General Surgery, The Fourth Affiliated Hospital of Henan University of Science and Technology,Anyang 455000, China

Received:2022-09-29 Online:2023-08-31 Published:2023-09-21

摘要/Abstract

摘要： 目的探讨超声内镜(EUS)引导下穿刺抽吸联合硬化剂注射术对肝囊肿患者炎症因子的影响。方法 2020年6月—2022年6月安阳市第三人民医院收治的肝囊肿患者90例,随机数字表法分为对照组和观察组各45例,依次行硬化剂注射术或者EUS引导下穿刺抽吸联合硬化剂注射术,观察48 周。比较两组治疗前及治疗后7 d血生化指标及炎因子水平,分析两组治疗后12 周总有效率及不良反应发生率,并观察两组治疗后48 周肝囊肿复发率。结果观察组治疗后12 周末总有效率为95.56%,高于对照组的82.22%(P<0.05)。两组治疗后7 d ALT、AST、ALP及TBil无显著差异(P>0.05)。观察组治疗后7 d血清CRP、TNF-α和IL-1β水平分别为(53.83±6.24)mg/L、(260.80±18.40)ng/L和(91.04±5.10)ng/L,显著低于对照组[(56.67±5.96)mg/L、(268.92±16.93)ng/L和(93.22±4.87)ng/L,P<0.05]。观察组不良反应发生率为2.22%,低于对照组的17.78%(P<0.05)。观察组治疗后48 周末肝囊肿复发率为2.27%,低于对照组的17.95%(P<0.05)。结论相较于硬化剂注射术,EUS引导下穿刺抽吸联合硬化剂注射术治疗肝囊肿临床疗效更为确切,可缓解机体炎症反应,减少并发症及复发,对患者肝功能并无明显影响。

关键词: 超声内镜, 细针穿刺抽吸术, 硬化剂注射术, 肝囊肿, 血清炎症因子

Abstract: Objective To investigate the effects of endoscopic ultrasound (EUS)-guided aspiration combined with sclerotherapy on serum inflammatory factors in patients with hepatic cysts.Methods From June 2020 to June 2022, 90 patients with hepatic cysts were admitted to our hospital. These patients were randomly divided into control group and observation group, with each group comprising 45 patients, The control group underwent sclerosing agent injection, while the observation group received EUS-guided percutaneous aspiration sclerotherapy, for a duration of 48 weeks. The levels of blood biochemical indexes and inflammatory factors between the two groups pre-treatment and 7 days post-treatment were compared. Further more, the total effective rate and the incidence of adverse reactions 12 weeks post-treatment in both groups were analyzed. Lastly, the recurrence rate of hepatic cysts 48 weeks after treatment in both groups was observed in the two groups.Results At the 12-week post-treatment mark, the observation group showed a higher total effective rate of 95.56% compared to the control group`s 82.22%e (P<0.05). There were no significant differences in ALT, AST, ALP and TBil between the two groups 7 days post-treatment (P>0.05). In the observation group, the serum levels of CRP, TNF-α and IL-1β were significantly lower[(53.83±6.24) mg/L, (260.80±18.40) ng/L and (91.04±5.10) ng/L, respectively] than those in the control group [(56.67±5.96) mg/L, (268.92±16.93) ng/L and (93.22±4.87) ng/L, P<0.05]. The incidence of adverse reactions in the observation group (2.22%) was also lower than that in the control group (17.78% , P<0.05). At the end of the 48-week post-treatment period, the observation group showed a lower recurrence rate of hepatic cysts( 2.27%) compared to the control group(17.95%, P<0.05).Conclusion In comparison to sclerotherapy injection alone, EUS-guided percutaneous aspiration sclerotherapy proves to be more effective for hepatic cysts. This approach can mitigate inflammation, diminish the incidence of complications and recurrence, without significantly impacting liver function.

Key words: Endoscopic ultrasound, Fine needle aspiration, Sclerosing agent injection, Liver cyst, Serum inflammatory factor

武建, 王连才, 王亚峰, 杜长顺, 肖建安. 超声内镜引导下穿刺抽吸联合硬化剂注射术治疗肝囊肿的疗效[J]. 肝脏, 2023, 28(8): 983-986.

WU Jian, WANG Lian-cai, WANG Ya-feng, DU Chang-shun, XIAO Jian-an. Effects of endoscopic ultrasound-guided percutaneous aspiration sclerotherapy on serum inflammatory factors in patients with hepatic cysts[J]. Chinese Hepatolgy, 2023, 28(8): 983-986.

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