sTfR、肝脾CT比值与老年非酒精性脂肪性肝病患者轻度认知功能障碍的相关性

肝脏 ›› 2024, Vol. 29 ›› Issue (1): 105-109.

sTfR、肝脾CT比值与老年非酒精性脂肪性肝病患者轻度认知功能障碍的相关性

张维, 刘清林, 张慢, 安阳, 曹睦涵

100078 北京中医大学东方医院检验科

收稿日期:2022-05-30 出版日期:2024-01-31 发布日期:2024-03-01
通讯作者: 刘清林
基金资助:
北京中医药大学基本科研业务费项目资助课题(2019-JYB-JS-115)

Correlation between sTfR, liver/spleen CT ratio and mild cognitive impairment in elderly patients with nonalcoholic fatty liver disease

ZHANG Wei, LIU Qing-lin, ZHANG Man, AN Yang, CAO Mu-han

Department of Laboratory ,Oriental Hospital of Beijing University of Traditional Chinese Medicine, Beijing 100078, China

Received:2022-05-30 Online:2024-01-31 Published:2024-03-01
Contact: LIU Qing-lin

摘要/Abstract

摘要： 目的探讨可溶性转铁蛋白受体(sTfR)、肝脾CT比值与非酒精性脂肪性肝病(NAFLD)患者轻度认知功能(MCI)的相关性。方法回顾性纳入2019年3月5日—2020年3月5日于北京中医药大学东方医院就诊的老年NAFLD患者110例和健康体检者50例,其中老年NAFLD患者蒙特利尔认知功能量表(MoCA)评分＜26分定义为MCI组(61例),MoCA≥26分定义为非MCI组(49例),健康体检者为对照组。收集并对比3组的基线资料差异,利用MoCA进行认知功能的评估,进一步采用Pearson相关性分析老年NAFLD患者MoCA评分与上述指标的相关性,然后采用logistic回归分析NAFLD患者MoCA评分＜26分(发生MCI)的危险因素。结果左侧NAA/Cr、右侧NAA/Cr、sTfR、肝脾CT比值在对照组、非MCI组、MCI组依次下降,组组比较差异有显著性(P<0.05);BMI≥25、TG、LDL-C、MoCA在对照组和非MCI组中比较差异无显著性(P>0.05),与对照组和非MCI组比较,MCI组BMI≥25、TG、LDL-C明显更高,MoCA明显更低(均P<0.05)。老年NAFLD患者MoCA评分与左侧NAA/Cr、右侧NAA/Cr、sTfR、肝脾CT比值呈正相关,与LDL-C呈负相关(P<0.05)。logistic回归分析显示,sTfR、肝脾CT比值、BMI≥25、TG是老年NAFLD患者发生MCI的危险因素(P<0.05)。结论 sTfR、肝脾CT比值是老年NAFLD患者MCI发生的危险因素,二者与其MCI发生均呈正相关。

关键词: 非酒精性脂肪性肝病, 轻度认知功能障碍, 可溶性转铁蛋白受体, 肝脾CT比值

Abstract: Objective To investigate the relationship between serum soluble transferrin receptor (sTfR), liver/spleen CT ratio and cognitive function in patients with nonalcoholic fatty liver disease (NAFLD). Methods A total of 110 elderly patients with NAFLD and 50 healthy people who were treated in Dongfang Hospital of Beijing University of Traditional Chinese Medicine from March 5, 2019 to March 5, 2020 were retrospectively included. The cognitive function was measured using the Montreal Cognitive Function Scale(MoCA). Among them, the elderly patients with NAFLD were classified into MCI group(MoCA>26, 61 cases) and non-MCI group(MoCA <26, 49 cases). Additionally, there were 50 healthy subjects assigned to the control group. The differences in the baseline data of the three groups were collected and compared, and the MoCA was used to evaluate the cognitive function. The Pearson correlation was further used to analyze the correlation between the MoCA score and the above indicators in elderly NAFLD patients, and then logistic regression was performed to analyze the correlation. Risk factors for NAFLD patients with MoCA score < 26 (MCI). Results The ratios of left NAA/Cr, right NAA/Cr, sTfR, liver/spleen CT ratio decreased in the control group, non-MCI group, and MCI group in turn, and the difference between groups was significant (P<0.05); No significant difference was found in the proportion of patients with BMI>25, MocA score, TG and LDL-C levels between the control group and non-MCI group. When compared with the control group and non-MCI group, the proportion of patients with BMI≥25, TG and LDL-C levels were significantly higher, and the MoCA scores were significantly lower (all P<0.05) in the MCI group, . MoCA score in elderly patients with NAFLD was positively correlated with left NAA/Cr, right NAA/Cr, sTfR, liver/spleen CT ratio, and negatively correlated with LDL-C level(P＜0.05). Logistic regression analysis showed that sTfR, liver/spleen CT ratio, BMI≥25, and TG level were risk factors for MCI in elderly patients with NAFLD (P＜0.05). Conclusion sTfR and liver/spleen CT ratio are risk factors for MCI in elderly patients with NAFLD, and both are positively correlated with MCI.

Key words: Nonalcoholic fatty liver disease, Mild cognitive impairment, Soluble transferrin receptor, Liver-spleen CT ratio

张维, 刘清林, 张慢, 安阳, 曹睦涵. sTfR、肝脾CT比值与老年非酒精性脂肪性肝病患者轻度认知功能障碍的相关性[J]. 肝脏, 2024, 29(1): 105-109.

ZHANG Wei, LIU Qing-lin, ZHANG Man, AN Yang, CAO Mu-han. Correlation between sTfR, liver/spleen CT ratio and mild cognitive impairment in elderly patients with nonalcoholic fatty liver disease[J]. Chinese Hepatolgy, 2024, 29(1): 105-109.

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