脂肪肝诊断中ElastPQ弹性成像技术检测肝硬度与肝纤维化评分及FIB-4指数的相关性分析

摘要/Abstract

摘要： 目的分析脂肪肝诊断中ElastPQ弹性成像技术检测肝硬度与肝纤维化评分(NFS)及肝纤维化指数(FIB-4)的相关性。方法选定江苏省南通市第三人民医院2019年10月—2020年10月接诊的30例单纯NAFLD患者作为观察1组,30例2型糖尿病(T2DM)合并NAFLD患者作为观察2组,选定江苏省南通市第三人民医院同期健康体检中心30例健康体检者作为对比组,均给予ElastPQ弹性成像检查,对比三组ElastPQ值、NFS评分、FIB-4指数,对比观察1组、观察2组中轻度、中度、重度患者ElastPQ值、NFS评分、FIB-4指数,Spearman相关性分析ElastPQ值与NFS评分、FIB-4指数的相关性。结果观察2组ElastPQ值(6.82±1.54)kPa、NFS评分(-0.42±0.12)分、FIB-4指数(2.82±0.32)均高于观察1组(5.75±1.02)kPa、(-1.05±0.25)分、(2.25±0.16),观察1组均高于对比组(4.02±0.11)kPa、(-1.68±0.34)分、(1.02±0.11),P<0.05(差异均具有统计学意义)。观察1组、观察2组中重度患者ElastPQ值、NFS评分、FIB-4指数均高于中度患者,中度患者均高于轻度患者,P<0.05(差异均具有统计学意义)。ElastPQ值与NFS评分、FIB-4指数均呈正相关性,P<0.05(r=4.967、5.011)(差异均具有统计学意义)。结论 NAFLD患者随着肝纤维化程度加重,ElastPQ值会逐渐增高,ElastPQ值与肝纤维化程度存在一定相关性,临床可通过彩超测量ElastPQ值,评估NAFLD患者肝纤维化程度。

关键词: 脂肪肝, ElastPQ弹性成像技术, 肝硬度, 非酒精性脂肪性肝病, 肝纤维化

Abstract: Objective To evaluate liver stiffness and non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) measured by ElastPQ elastography, and to investigate their correlation with liver fibrosis index (FIB-4) in the diagnosis of fatty liver. Methods A total of 30 patients with pure NAFLD and 30 patients with type 2 diabetes mellitus (T2DM) combined with NAFLD were selected as observation group 1 and 2, respectively, from the Third People's Hospital of Nantong City, Jiangsu Province, between October 2019 and October 2020. Additionally, 30 healthy subjects from the health examination center of the same hospital during the same period were selected as the comparison group. All participants underwent ElastPQ elastography. The ElastPQ value, NFS score, and FIB-4 index of mild, moderate and severe patients in the two groups were observed. The correlation between ElastPQ value and NFS score and FIB-4 index was analyzed by Spearman correlation analysis. Results The ElastPQ value (6.82±1.54) kPa, NFS score (-0.42±0.12), and FIB-4 index (2.82±0.32) of observation group 2 were significantly higher than those of observation group 1 [(5.75±1.02) kPa, (-1.05±0.25), (2.25±0.16)], respectively. Additionally, the ElastPQ values, NFS score, and FIB-4 index of observation group 1 were higher than those in the comparison group [(4.02±0.11)kPa, (-1.68±0.34), (1.02±0.11)], respectively. These differences were all statistically significant, P＜0.05. The ElastPQ value, NFS score, and FIB-4 index of moderate-severe patients in observation group 1 and observation group 2 were higher than those in moderate patients, and those in moderate patients were higher than those in mild patients, P<0.05 (all differences were statistically significant). ElastPQ value was positively correlated with NFS score and FIB-4 index, P<0.05 (r=4.967, 5.011) (the difference was statistically significant). Conclusion The ElastPQ value demonstrates a gradual increase with the progression of liver fibrosis in NAFLD patients. There is a discernible correlation between the ElastPQ value and the extent of liver fibrosis. Clinically, the ElastPQ value can be measured by color Doppler ultrasound to evaluate the degree of liver fibrosis in NAFLD patients.

Key words: Fatty liver, ElastPQ elastography, Liver stiffness, Nonalcoholic fatty liver disease, Liver fibrosis

吴彬彬, 徐小琴, 顾星星, 解其华. 脂肪肝诊断中ElastPQ弹性成像技术检测肝硬度与肝纤维化评分及FIB-4指数的相关性分析[J]. 肝脏, 2024, 29(1): 73-76.

WU Bin-bin, XU Xiao-qin, GU Xing-xing, XIE Qi-hua. Correlation analysis of liver stiffness detected by ElastPQ elastography with nonalcoholic fatty liver disease fibrosis score (NFS) and FIB-4 index in the diagnosis of fatty liver[J]. Chinese Hepatolgy, 2024, 29(1): 73-76.

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