关键词: 肝病, 睡眠质量, 影响因素

Abstract: Objective To investigate and analyze the sleep patterns and their influencing factors among patients suffering from varous liver diseases, thereby offering a scientific foundation for enhancing quality. Methods Clinical data from patients diagnosed with liver disease at Beijing Friendship Hospital, affiliated with Capital Medical University, were systematically gathered through electronic medical records system from August to October 2022 . The Pittsburgh Sleep Quality index (PSQI) scale was employed to evaluate the severity and nature of sleep disorders among these patients. Based on the severity of their sleep disorders, patients were categorized into 4 distinct groups to facilitate a comparative analysis of clinical characteristics across varying degrees of sleep disorder severity in liver disease patients. Furthermore, logistic regression analysis was utilized to identify risk factors associated with severe sleep disorders in this hospitalized cohort. Results This study encompassed a cohort of 204 patients afflicted with liver diseases, among which 97 (47.55%) were male and 107 (52.45%) were female. The median age of participants was 58 (48, 66) years. The median PSQI score among the subjects was 4 (7, 10). A total of 76 patients (37.25%) were identified without a sleep disorder, whereas 128 patients (62.75%) were diagnosed with a sleep disorder. This subgroup was further divided into 78 cases (38.24%) with mild sleep disorder, 39 cases (19.12%) with moderate sleep disorder, and 11 cases (5.39%) with severe sleep disorder. The predominant sleep disorder,symptoms reported included difficulty initiating sleep (118, 57.84%), and nocturnal or early morning awakenings (111, 54.41%). The analysis revealed no statistically significant correlation between the severity of sleep disorders and the type or severity of liver (all P>0.05), However, age (HR 1.061, 95% CI: 1.006, 1.125) and serum alanine aminotransferase (ALT) levels (HR 1.003, 95% CI: 1.001,1.006) emerged as independent risk factors for severe sleep disorders in the studied population. Conclusion Ssleep disorders exhibit a high prevalence among hospitalized patients suffering from liver disease, with a notably higher incidence obersed in middle-aged individuals or those experiencing severe liver injury. Clinically, it is imperative to focus on elderly patients presenting with eleated serum ALT levels, promptly provide sleep management guidance, and deploy effective intervention strategies. These measures aim to enhace sleep quality and ultimately elevate the quality of life.

Key words: Liver diseases, Sleep quality, Influencing factors