关键词: 肝移植, 血糖, 影响因素, 儿童

Abstract: Objective To evaluate postoperative blood glucose dynamics and determinants in pediatric liver transplant patients. Methods In an observational study, dynamic data were collected from pediatric liver transplant recipents, encompassing routine blood tests, liver transplant biochemistry profiles, cyclosporine drug levels, fasting blood glucose, and glycated hemoglobin measurements. Subsequenty, these data underwent comprehensive statistical analysis to elucidate patterns and outcomes. Results A total of 51 pediatric liver transplant recipients were included in this study, including 31 males (60.8%) and 20 females (39.2%). The age range was 3-66 months, with an average of 11.7 ± 14.9 months. The height range was 54-116 cm, with an average of 69.4 ± 14.1 cm. The weight range was 3.8-22.0 kg, with an average of 8.0 ± 3.8 kg. Fasting blood glucose and glycated hemoglobin both reached their peaks on the first day after surgery, with values of 6.70 ± 1.85 mmol/L and 4.4 ± 0.4%, respectively, and gradually returned to preoperative levels. Lactate levels peaked at 15 minutes in the early post-transplant period, and the data was 2.89±0.95mmol/L. On the first day after surgery, there was a statistically significant difference in height (62.5[58.5,66.0]cm VS 67.0[63.0,75.0]cm) and weight (5.8[5.1,7.4]kg VS 7.8[6.4,9.5]kg) between the normal and abnormal groups in terms of fasting blood glucose. On the first and seventh day after surgery, there was a statistically significant difference in intraoperative blood transfusion between the normal and abnormal groups in terms of glycosylated hemoglobin. On the 14th day after surgery, there was a statistically significant difference in albumin levels (41.9±5.97 VS 38.59±4.14 g/L) between the normal and abnormal groups in terms of glycosylated hemoglobin. All p values were less than 0.05. Conclusion Fasting blood glucose levels and glycosylated hemoglobin exceeded normal values on the first day after liver transplantation. And height, weight, transfusion during surgery and hypoalbuminemia may be influencing factors for fasting blood glucose and glycated hemoglobin levels.

Key words: liver transplantation, blood glucose, influencing factor, pediatric