DNA甲基化在肝纤维化中的研究进展

摘要/Abstract

摘要： 肝纤维化是一种由诸多理化因子共同作用下形成的肝内纤维结缔组织异常增殖的疾病阶段,促纤维化与抗纤维化基因机制失衡是肝纤维化的中心环节。DNA甲基化作为一种常用的表观遗传修饰途径,通过修改基因结构从而影响相关因子的功能表现。目前资料表明,纤维化相关基因甲基化程度与疾病的进展密切相关。本文就DNA甲基化在肝纤维化中的具体机制及近年来的研究进展作一综述,以期为肝病的病情评价、初步诊断及靶向治疗提供新思路。

关键词: 肝纤维化, 肝星状细胞, 表观遗传, DNA甲基化, 调控基因

蒋月, 王建青. DNA甲基化在肝纤维化中的研究进展[J]. 肝脏, 2024, 29(4): 468-471.

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