增强MRI多模态参数与原发性肝癌患者肝功能分级的相关性分析

肝脏 ›› 2024, Vol. 29 ›› Issue (6): 667-670.

增强MRI多模态参数与原发性肝癌患者肝功能分级的相关性分析

陈延霞, 阿妮, 徐旋, 白荣, 刘小治

716000 陕西延安大学附属医院放射科(陈延霞);716000 延安市人民医院CT诊断科(阿妮,白荣,刘小治),放射科(徐旋)

收稿日期:2024-01-30 出版日期:2024-06-30 发布日期:2024-08-28
通讯作者: 阿妮,Email:562640748@qq.com
基金资助:
陕西省自然科学基础研究计划项目(2022JM-575)

Correlation analysis of enhanced MRI multimodal parameters and liver function grading in patients with primary liver cancer

CHEN Yan-xia¹, A Ni², XU Xuan³, BAI Rong², LIU Xiao-zhi²

1. Department of Radiology,Yan'an University Affiliated Hospital, Shaanxi 716000,China;
2. Department of CT Diagnosis,Yan'an People's Hospital, Shaanxi 716000,China;
3. Department of Radiology,Yan'an People's Hospital, Shaanxi 716000, China

Received:2024-01-30 Online:2024-06-30 Published:2024-08-28
Contact: A Ni,Email:562640748@qq.com

摘要/Abstract

摘要： 目的分析增强磁共振成像(MRI)多模态参数与原发性肝癌患者肝功能分级的相关性。方法选择2020年9月—2023年9月在延安大学附属医院进行治疗的70例原发性肝癌患者作为研究对象,依据Child-Pugh分级将其分为A级(n=21)、B级(n=36)、C级(n=13)。比较增强MRI与手术病理分级的一致性、不同肝功能分级患者的增强MRI多模态参数,采用Spearman秩相关分析增强MRI多模态参数与原发性肝癌患者肝功能分级的相关性。结果经一致性分析证实,增强MRI与手术病理分级的准确率91.43%、灵敏度90.48%、特异度92.86%、阳性预测值95.00%、阴性预测值92.86%、Kappa值=0.824;肝功能A级患者的T1、D*及f值[(503.49±40.32)ms、(61.35±5.89)×10^-3 mm²/s、(28.65±3.27)%]均低于肝功能B级患者[(545.67±45.39)ms、(65.87±6.36)×10^-3 mm²/s、(33.26±3.82)%],T2,ADC及D值[(73.56±6.82)ms、(1.67±0.32)×10^-3 mm²/s、(1.47±0.19)×10^-3 mm²/s]高于肝功能B级患者[(65.43±5.89)ms、(1.41±0.26)×10^-3 mm²/s、(1.28±0.16)×10^-3 mm²/s],肝功能B级患者的T1、D*及f值均低于肝功能C级患者[(575.52±56.31)ms、(71.33±6.52)×10^-3 mm²/s、(36.13±4.36)%],T2,ADC及D值高于肝功能C级患者[(61.26±5.37)ms、(1.24±0.19)×10^-3 mm²/s、(1.06±0.13)×10^-3 mm²/s](P<0.05);相关性分析显示,T1、D*及f值与原发性肝癌患者肝功能分级呈正相关(r=0.535、0.432、0.519,P<0.05),T2、ADC及D值与原发性肝癌患者肝功能分级呈负相关(r=-0.426、-0.597、-0.524,P<0.05)。结论增强磁共振成像(MRI)多模态参数可有效判断原发性肝癌患者肝功能损害程度,临床诊治时可结合以上结果制定针对性治疗方案。

关键词: 增强磁共振成像多模态参数, 原发性肝癌, 肝功能分级, 相关性

Abstract: Objective To analyze the correlation between multimodal parameters of enhanced magnetic resonance imaging (MRI) and liver function grading in patients with primary liver cancer. Methods Seventy patients with primary liver cancer treated at the hospital from September 2020 to September 2023 were enrolled, and were divided into grade A (n=21), grade B (n=36) and grade C (n=13) according to Child-Pugh classification. Spearman rank correlation analysis was used to compare the consistency of enhanced MRI with surgical pathological grade and the correlation of enhanced MRI multimodal parameters with liver function grade in patients with primary liver cancer. Results Consistency analysis showed that the accuracy, sensitivity, specificity, positive predictive value, negative predictive value and Kappa value were 91.43%, 90.48%, 92.86%, 95.00%, 92.86%, 0.824, respectively. The T1, D* and f values [(503.49±40.32) ms, (61.35±5.89) ×10^-3 mm²/s, (28.65±3.27) %] of patients with liver function grade A were lower than those of patients with liver function grade B [(545.67±45.39) ms, (65.87±6.36) ×10^-3 mm²/ s, (33.26±3.82) %]. T2, ADC and D values [(73.56±6.82) ms, (1.67±0.32) ×10^-3 mm²/s, (1.47±0.19) ×10^-3 mm²/s] were higher than those with grade B liver function [(65.43±5.89) ms, (1.41±0.26) ×10^-3 mm²/s, (1.2 8±0.16) ×10^-3 mm²/s]. T1, D* and f values of patients with liver function grade B were lower than those of patients with grade C liver function [(575.52±56.31) ms, (71.33±6.52) ×10^-3 mm²/s, (36.13±4.36) %]. T2, ADC and D values were significantly higher than those with grade C liver function [(61.26±5.37) ms, (1.24±0.19) ×10^-3 mm²/s, (1.06±0.13) ×10^-3 mm²/s] (P<0.05). Correlation analysis showed that T1, D* and f values were positively correlated with liver function grade in patients with primary liver cancer (r=0.535, 0.432, 0.519, P<0.05), while T2, ADC and D values were negatively correlated with liver function grade (r=-0.426, -0.597, -0.524, P<0.05). Conclusion Enhanced magnetic resonance imaging (MRI) multimodal parameters can effectively modify the degree of liver function in patients with primary liver cancer, and can be combined with the above results in clinical diagnosis and treatment plan.

Key words: Multimodal parameters of enhanced magnetic resonance imaging, Primary liver cancer, Liver function classification, Correlation

陈延霞, 阿妮, 徐旋, 白荣, 刘小治. 增强MRI多模态参数与原发性肝癌患者肝功能分级的相关性分析[J]. 肝脏, 2024, 29(6): 667-670.

CHEN Yan-xia, A Ni, XU Xuan, BAI Rong, LIU Xiao-zhi. Correlation analysis of enhanced MRI multimodal parameters and liver function grading in patients with primary liver cancer[J]. Chinese Hepatolgy, 2024, 29(6): 667-670.

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