[1] Xiao J, Wang F, Wong NK, et al. Global liver disease burdens and research trends: Analysis from a Chinese perspective[J]. J Hepatol,2019,71:212-221. [2] Mun SJ, Ryu JS, Lee MO, et al. Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids[J]. J Hepatol,2019,71:970-985. [3] Raven A, Lu WY, Man TY, et al. Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration[J]. Nature,2017,547:350-354. [4] Tarlow BD, Pelz C, Naugler WE, et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes[J]. Cell Stem Cell,2014,15:605-618. [5] Huch M, Gehart H, van Boxtel R, et al. Long-term culture of genome-stable bipotent stem cells from adult human liver[J]. Cell,2015,160:299-312. [6] Wu H, Zhou X, Fu GB, et al. Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion[J]. Cell Res,2017,27:709-712. [7] Fu GB, Huang WJ, Zeng M, et al. Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens[J]. Cell Res,2019,29:8-22. [8] Katsuda T, Kawamata M, Hagiwara K, et al. Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity[J]. Cell Stem Cell,2017,20:41-55. [9] Hu H, Gehart H, Artegiani B, et al. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids[J]. Cell,2018,175:1591-1606.e1519. [10] Young RA. Control of the embryonic stem cell state[J]. Cell,2011,144:940-954. [11] Poetsch MS, Strano A, Guan K. Human Induced Pluripotent Stem Cells: From Cell Origin, Genomic Stability, and Epigenetic Memory to Translational Medicine[J]. Stem Cells, 2022,40:546-555. [12] Yuan Y, Cotton K, Samarasekera D, et al. Engineered Platforms for Maturing Pluripotent Stem Cell-Derived Liver Cells for Disease Modeling[J]. Cell Mol Gastroenterol Hepatol, 2023,15:1147-1160. [13] Volpato V, Webber C. Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility[J]. Dis Model Mech,2020. [14] Yousef Yengej FA, Jansen J, Ammerlaan CME, et al. Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoidsAddressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility[J]. Proc Natl Acad Sci U S A,2023,120:e2216836120. [15] Yoshihara M, Hayashizaki Y, Murakawa Y. Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications[J]. Stem Cell Rev Rep,2017,13:7-16. [16] King NM, Perrin J. Ethical issues in stem cell research and therap[J]y. Stem Cell Res Ther, 2014,5:85. [17] Corbett JL, Duncan SA. iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery[J]. Front Med (Lausanne),2019,6:265. [18] Hendriks D, Brouwers JF, Hamer K, et al. Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis[J]. Nat Biotechnol,2023,41:1567-1581. [19] Warren CR, O'Sullivan JF, Friesen M, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease[J]. Cell Stem Cell, 2017,20:547-557.e547. [20] Shinozawa T, Kimura M, Cai Y, et al. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids[J]. Gastroenterology, 2021,160:831-846.e810. [21] Ware BR, Berger DR, Khetani SR. Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes[J]. Toxicol Sci, 2015,145:252-262. [22] Leite SB, Roosens T, El Taghdouini A, et al. Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in?vitro[J]. Biomaterials,2016,78:1-10. [23] Lee JY, Han HJ, Lee SJ, et al. Use of 3D Human Liver Organoids to Predict Drug-Induced Phospholipidosis[J]. Int J Mol Sci,2020,21. [24] Scoon WA, Mancio-Silva L, Suder EL, et al. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes[J]. Stem Cell Rep,2022,17:2286-2302. [25] Wang J, Qu B, Zhang F, et al. Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research[J]. Stem Cells Int, 2019,2019:9605252. [26] Dao Thi VL, Wu X, Belote RL, et al. Stem cell-derived polarized hepatocytes[J]. Nat Commun,2020,11:1677. [27] Yang L, Han Y, Nilsson-Payant BE, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids[J]. Cell Stem Cell,2020,27:125-136.e127. |