青少年学生血尿酸水平与非酒精性脂肪性肝病发生、发展的关系

肝脏 ›› 2025, Vol. 30 ›› Issue (1): 87-90.

青少年学生血尿酸水平与非酒精性脂肪性肝病发生、发展的关系

丁剑波, 李丽, 李秀惠

101101 北京卫生职业学院(丁剑波);100010 首都医科大学附属北京中医医院肝病科(李丽);100069 首都医科大学附属北京佑安医院中西医结合中心(李秀惠)

收稿日期:2023-10-19 出版日期:2025-01-31 发布日期:2025-03-10
通讯作者: 李丽,Email:bjfhlc@126.com;李秀惠,Email:lixiuhui@sohu.com
基金资助:
中华中医药学会资助项目(202172-001)

The relationship between blood uric acid levels and the incidence and progression of non-alcoholic fatty liver disease in adolescent students

DING Jian-bo¹, LI Li², LI Xiu-hui³

1. Beijing Health Vocational College, Beijing 101101, China;
2. Department of Hepatology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China;
3. Integrated Chinese and Western Medicine Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China

Received:2023-10-19 Online:2025-01-31 Published:2025-03-10
Contact: LI Li, Email: bjfhlc@126.com; LI Xiu-hui, Email: lixiuhui@sohu.com

摘要/Abstract

摘要： 目的研究患非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)的青少年学生血尿酸水平、丙氨酸氨基转移酶(Alanine aminotransferase, ALT)水平情况,以及血尿酸水平与青少年NAFLD患病率、ALT的相关性。方法通过对北京市某高校2017年—2019年共312名青少年学生的入校体检数据回顾性统计,分析NAFLD的患病率,比较患NAFLD与未患NAFLD的青少年学生的ALT、尿酸的差异,并统计尿酸与NAFLD的关系以及尿酸与ALT的相关性。结果在本研究中青少年学生NAFLD的患病率为23.4%,其中男性患病率26.8%、女性患病率18%,未成年青少年患病率25.6%,成年青少年患病率为18.6%,差异均没有统计学意义;患NAFLD的青少年学生肝损伤的指标ALT已明显升高(P<0.05),患NAFLD青少年学生比非NAFLD青少年学生尿酸水平明显升高[(418.45±77.65)比(357.35±83.21)μmol/L]。尿酸正常的青少年学生NAFLD患病率为16.5%,高尿酸(＞420 μmol/L)的青少年学生NAFLD患病率为40.9%,差异有统计学意义(P<0.05),进一步行logistic回归分析表明,尿酸是NAFLD发生的危险因素,优势比OR值为3.50,说明在其他因素不变的情形下高尿酸的青少年学生发生NAFLD是尿酸正常者的3.5倍。而且尿酸水平与ALT呈显著正相关,相关系数=0.27。结论患NAFLD青少年学生已出现肝损伤、尿酸水平升高,而且高尿酸是NAFLD发生的危险因素,而且在一定程度上随着尿酸升高会出现肝损伤加重。

关键词: 青少年, 肝损伤, 尿酸, 高尿酸血症, 非酒精性脂肪性肝病, 代谢相关脂肪性肝病

Abstract: Objective To study the levels of blood uric acid and alanine aminotransferase (ALT) in adolescent students with non-alcoholic fatty liver disease (NAFLD), and further explore the correlation between blood uric acid levels and the prevalence of NAFLD and ALT in adolescent students. Methods A retrospective analysis was conducted on the physical examination data of 312 adolescent students of a university in Beijing from 2017 to 2019. The prevalence of NAFLD was analyzed and the differences in ALT and uric acid levels between adolescent students with and without NAFLD were compared. And analyze the relationship between uric acid and NAFLD, as well as the correlation between uric acid and ALT. Methods In this study, the prevalence of NAFLD among adolescent students was 23.4%. The prevalence rate for males was 26.8%, for females was 18%, for underage adolescents was 25.6%, and for adult adolescents was 18.6% (P>0.05). The ALT levels in adolescent students with NAFLD have significantly increased (P<0.05). Adolescent students with NAFLD have significantly higher levels of uric acid compared to non NAFLD students (418.45 ± 77.65 μmol/L vs 357.35 ± 83.21 μmol/L). The prevalence of NAFLD in adolescent students with normal uric acid was 16.5%, and with hyperuricemia(>420 μmol/L)was 40.9% (P<0.05). Logistic regression analysis showed that uric acid was a risk factor for the occurrence of NAFLD (Odds ratio = 3.50), indicating that the adolescent students with hyperuricemia were 3.5 times more likely to develop NAFLD than those with normal uric acid, while other factors remain unchanged. Moreover, there was a significant positive correlation between uric acid and ALT. Conclusion Adolescent students with NAFLD have developed liver injury and elevated uric acid levels. Moreover, high uric acid is a risk factor for the occurrence of NAFLD, and as uric acid increases, liver damage will worsen to a certain extent.

Key words: Adolescent, Liver injury, Uric acid, Hyperuricemia, Non-alcoholic fatty liver disease, Metabolic associated fatty liver disease

丁剑波, 李丽, 李秀惠. 青少年学生血尿酸水平与非酒精性脂肪性肝病发生、发展的关系[J]. 肝脏, 2025, 30(1): 87-90.

DING Jian-bo, LI Li, LI Xiu-hui. The relationship between blood uric acid levels and the incidence and progression of non-alcoholic fatty liver disease in adolescent students[J]. Chinese Hepatolgy, 2025, 30(1): 87-90.

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