血清IL-8水平与胆道闭锁患者Kasai术后自体肝生存时间的相关性分析

肝脏 ›› 2025, Vol. 30 ›› Issue (12): 1714-1719.

血清IL-8水平与胆道闭锁患者Kasai术后自体肝生存时间的相关性分析

刘立伟, 王艳, 李珊珊, 朱志军, 陈煜, 赵新颜

100069 北京首都医科大学附属北京佑安医院肝病中心四科(刘立伟,李珊珊,陈煜);100050 北京首都医科大学附属北京友谊医院肝病中心(王艳,朱志军,赵新颜)

收稿日期:2025-06-24 发布日期:2026-02-10
通讯作者: 赵新颜,Email:zhao_xinyan@ccmu.edu.cn;陈煜,Email:chybeyond1071@ccmu.edu.cn
基金资助:
首都医科大学附属北京佑安医院中青年人才孵育项目(BJYAYY-CY2024-21)

Correlation analysis between serum IL-8 level and native liver survival time in patients with biliary atresia after Kasai procedure

LIU Li-wei¹, WANG Yan², LI Shan-shan¹, ZHU Zhi-jun², CHEN Yu¹, ZHAO Xin-yan²

1. Fourth Department of Liver Disease, Beijing You'an Hospital, Capital Medical University, Beijing 100069, China;
2. Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2025-06-24 Published:2026-02-10
Contact: ZHAO Xin-yan, Email:zhao_xinyan@ccmu.edu.cn; CHEN Yu, Email:chybeyond1071@ccmu.edu.cn

摘要/Abstract

摘要： 目的探讨细胞因子是否能够早期识别Kasai术(KP)后自体肝生存时间短的患者。方法纳入2017年7月至2019年6月因胆道闭锁进行肝移植手术的患儿,所有患者在移植前均已接受Kasai手术。根据KP术后自体肝生存时间是否超过1年,将患者分为两组:KP术后自体肝早期衰竭组(KP-EF)和晚期衰竭组(KP-LF)。收集两组人口学资料、实验室数据和病理资料,并检测血清中38种细胞因子水平,比较与预后的相关性。结果与KP-LF组相比,KP-EF组患者的IL-8水平显著更高(121.4±142.7 vs. 43.3±68.3,P<0.05)。IL-8水平与KP术后自体肝生存时间呈负相关(R=-0.584,P<0.001),同时与Child-Pugh评分和PELD评分均呈正相关(R分别为0.438和0.481,P值均＜0.05)。结论在胆道闭锁患者中,KP术后自体肝生存时间越短,IL-8水平越高,且预后更差。IL-8可能为临床医生早期识别自体肝早期衰竭患者提供重要参考。

关键词: 胆道闭锁, 自体肝生存时间, 白介素-8, 肝移植

Abstract: Objective This study aims to investigate whether cytokines examination can early identify patients with short-term native liver survival time after Kasai procedure (KP), thereby providing a basis for early liver transplantation in this group of patients and improving postoperative outcomes. Methods This study included children who underwent liver transplantation due to biliary atresia (BA) from July 2017 to June 2019, all of whom had previously undergone the KP. Based on whether the native liver survival time after KP exceeded one year, patients were divided into two groups: the early failure group (KP-EF) and the late failure group (KP-LF). We collected demographic data, laboratory results, and pathological information, and assessed the levels of 38 serum cytokines and their correlation with prognosis. Results Compared to the KP-LF group, the KP-EF group had significantly higher levels of IL-8 (121.4±142.7 vs. 43.3±68.3, P<0.05). IL-8 levels were negatively correlated with autologous liver survival time after KP (R=-0.584, P<0.001) and positively correlated with both Child-Pugh and PELD scores (R values of 0.438 and 0.481, respectively, P<0.05). Conclusion In patients with BA, short-term native liver survival time after KP is associated with higher levels of IL-8 and poorer prognosis. IL-8 may provide important insights for clinicians to early identify patients with early liver failure.

Key words: Biliary atresia, Native liver survival time, Interleukin-8, Liver transplantation

刘立伟, 王艳, 李珊珊, 朱志军, 陈煜, 赵新颜. 血清IL-8水平与胆道闭锁患者Kasai术后自体肝生存时间的相关性分析[J]. 肝脏, 2025, 30(12): 1714-1719.

LIU Li-wei, WANG Yan, LI Shan-shan, ZHU Zhi-jun, CHEN Yu, ZHAO Xin-yan. Correlation analysis between serum IL-8 level and native liver survival time in patients with biliary atresia after Kasai procedure[J]. Chinese Hepatolgy, 2025, 30(12): 1714-1719.

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