STE/STQ检查乙型肝炎肝纤维化患者肝硬度值的影响因素研究

摘要/Abstract

摘要： 目的分析声触诊弹性成像(STE)/声触诊弹性测量(STQ)检查乙型肝炎肝纤维化患者肝硬度值(LSM)的影响因素。方法回顾性分析2018年1月—2023年12月在我院进行治疗的80例乙型肝炎肝纤维化患者的临床资料,依据患者肝纤维化程度进行分组,F1期组(n=20),F2期组(n=23),F3期组(n=15),F4期组(n=22)。比较各组患者基线资料信息、实验室指标[丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、凝血酶原时间、部分活化凝血活酶时间]及STE肝硬度值、STQ肝硬度值,对STE肝硬度值、STQ肝硬度值与ALT、AST的相关性采用相关性分析。结果 F4期组ALT、AST、LSMSTE、LSMSTQ[(260.62±36.13)U/L、(120.97±23.65)U/L、(18.52±4.63)kPa、(19.24±5.33)kPa]高于F1、F2、F3期患者,F3期组ALT、AST、LSMSTE、LSMSTQ[(237.46±35.67)U/L、(105.43±21.33)U/L、(14.21±3.94)kPa、(14.83±4.62)kPa]高于F1、F2期患者,F2期组ALT、AST、LSMSTE、LSMSTQ[(207.32±33.58)U/L、(90.45±20.71)U/L、(11.63±3.58)kPa、(12.45±3.94)kPa]高于F1期患者[(185.33±30.64)U/L、(76.54±19.26)U/L、(8.32±1.56)kPa、(8.99±2.03)kPa](P<0.05);相关性分析显示,LSMSTE、LSMSTQ与ALT、AST呈正相关(r=0.658、0.531、0.613、0.594,P<0.05)。结论 ALT、AST与LSM关系密切,将影响STE/STQ检查乙型肝炎肝纤维化结果,在临床评估肝纤维化程度时,需结合影像学和实验室检查结果进行综合判断,进一步提高诊断准确率。

关键词: 声触诊弹性成像, 声触诊弹性测量, 乙型肝炎, 肝纤维化, 肝硬度值

Abstract: Objective To analyze the influence factors of liver stiffness values (LSM) of hepatitis B patients with liver fibrosis determined by sonopalpation elastography (STE) and sonopalpation elastometry (STQ). Methods The clinical data of 80 patients with hepatitis B-related liver fibrosis treated in our hospital from January 2018 to December 2023 were retrospectively analyzed. The patients were divided into F1 (n=20), F2 (n=23), F3 (n=15), and F4 (n=22) groups according to the degree of liver fibrosis. Baseline data, laboratory indicators including alanine aminotransferase (ALT], aspartate aminotransferase (AST), prothrombin time, partially activated thrombin time, liver stiffness values of STE and STQ in all groups were compared. Correlation analysis was conducted to analyze the correlation between liver hardness values of STE and STQ, and the levels of ALT and AST. Results The levels of ALT, AST, LSMSTE and LSMSTQ in stage F4 group were (260.62±36.13)U/L, (120.97±23.65) U/L, (18.52±4.63) kPa, and (19.24±5.33) kPa, respectively, which were higher than those in stage F1, F2 and F3 patients. The levels of ALT, AST, LSMSTE, LSMSTQ in stage F3 group were 237.46±35.67) U/L, (105.43±21.33) U/L, (14.21±3.94) kPa, and (14.83±4.62) kPa, which were higher than those in stage F1 and F2 patients. Similarly, the levels of ALT, AST, LSMSTE, and LSMSTQ in stage F2 group were (207.32±33.58) U/L, (90.45±20.71) U/L, (11.63±3.58) kPa, and (12.45±3.94) kPa, respectively, which were higher than those of (185.33±30.64) U/L, (185.33±30.64) U/L, (76.54±19.26) U/L, (8.32±1.56) kPa, and (8.99±2.03) kPa in stage F1 patients (P<0.05); Correlation analysis showed that LSMSTE and LSMSTQ values were positively correlated with the levels of ALT and AST (r=0.658, 0.531, 0.613, 0.594, P<0.05). Conclusion The levels of ALT and AST are closely related to LSM, which may affect the results of STE/STQ in the examination of hepatitis B liver fibrosis. In the clinical evaluation of the degree of liver fibrosis, imaging and laboratory examination results should be comprehensively judged to further improve the diagnostic accuracy.

Key words: Acoustic palpation elastography, Sound palpation elasticity measurement, Hepatitis B, Liver fibrosis, Liver stifness

孙静, 钱奎. STE/STQ检查乙型肝炎肝纤维化患者肝硬度值的影响因素研究[J]. 肝脏, 2025, 30(5): 617-619.

SUN Jing, QIAN Kui. A study on the influencing factors of liver stiffness in hepatitis B patients with liver fibrosis by STE/STQ[J]. Chinese Hepatolgy, 2025, 30(5): 617-619.

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