EGF rs4444903基因多态性与HCV感染相关肝细胞癌风险相关:一项Meta分析

肝脏 ›› 2025, Vol. 30 ›› Issue (5): 624-629.

EGF rs4444903基因多态性与HCV感染相关肝细胞癌风险相关:一项Meta分析

王辉, 边娜娜, 冯巩, 张粉娜, 孙荣荣, 张心怡, 王梓依, 贺娜

710077 陕西西安西安医学院第一附属医院 (王辉,边娜娜,张粉娜,孙荣荣,张心怡,王梓依,贺娜);西安医学院(冯巩)

收稿日期:2024-02-20 出版日期:2025-05-31 发布日期:2025-07-04
通讯作者: 贺娜,Email:ylhena@163.com
作者简介:共同第一作者:边娜娜
基金资助:
佑安肝病传染病专科医疗联盟专项基金(LM202003);陕西省教育科学“十三五”规划课题(SGH20Y1330);2022年度陕西基础科学(化学、生物学)研究院科学研究计划项目(22JHQ091)

EGF rs4444903 gene polymorphism is associated with the risk of HCV infection-related hepatocellular carcinoma: a Meta-analysis

WANG Hui¹, BIAN Na-na¹, FENG Gong², ZHANG Fen-na¹, ZHANG Xin-yi¹, WANG Zi-yi¹, SUN Rong-rong¹, HE Na¹

1.The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, China;
2. Xi'an Medical University, Xi'an, Shaanxi 710021, China

Received:2024-02-20 Online:2025-05-31 Published:2025-07-04
Contact: HE Na,Email:ylhena@163.com

摘要/Abstract

摘要： 目的探讨EGF rs4444903位点多态性与HCV相关肝细胞癌发生风险的关系。方法计算机检索PubMed、中国知网、万方、Springer 、Cochrane、Embase数据库中EGF rs4444903位点多态性与HCV相关肝细胞癌发生风险的病例对照研究。应用Stata 17.0软件进行meta分析,计算合并OR及95%CI,并进行敏感性分析,以及发表偏倚的评价。结果共纳入5篇病例对照研究,结果显示EGF rs4444903基因多态性与HCV相关肝细胞癌风险显著相关。等位基因模型G vs. A(OR=1.48,95%CI:1.22~1.80,P=0.001);纯合模型GG vs. AA(OR=2.54,95%CI:1.65~3.91,P=0.001);隐性模型GG vs. GA+AA(OR=1.76,95%CI:1.16~2.66,P=0.01)。结论 EGF rs4444903基因多态性与HCV相关肝细胞癌风险显著相关。

关键词: EGF, 基因多态性, 丙型肝炎病毒, 肝细胞癌, Meta分析

Abstract: Objective To investigate the association between EGF polymorphisms on rs4444903 locus and the risk of HCV infection-related hepatocellular carcinoma (HCC). Methods A computer-based search was performed on all case-control studies in the databases of PubMed, CNKI, Wan Fang Date, Springer-Verlag, Cochrane and Embase to identify the association of EGF rs4444903 polymorphisms with the risk of HCV infection-related HCC. Meta-analysis was performed by applying Stata 17.0 software, and the OR and 95% CI were calculated. A sensitivity analysis was performed, and the publication bias was evaluated. Results A total of five case-control studies were included in this meta-analysis study. It was shown that EGF rs4444903 gene polymorphisms were significantly associated with the risk of HCV infection-related HCC: 1) allelic model G vs A: (OR=1.48, 95% CI: 1.22~1.80, P=0.001); 2) pure model GG vs AA: (OR=2.54, 95% CI: 1.65~3.91, P=0.001); 3) recessive model GG vs GA+AA: (OR=1.76, 95% CI: 1.16~2.66, P=0.01). Conclusion EGF rs4444903 gene polymorphism was significantly associated with the risk of HCV infection-related HCC.

Key words: EGF, Polymorphism, Hepatitis C virus, Hepatocellular carcinoma, Meta-analysis

王辉, 边娜娜, 冯巩, 张粉娜, 孙荣荣, 张心怡, 王梓依, 贺娜. EGF rs4444903基因多态性与HCV感染相关肝细胞癌风险相关:一项Meta分析[J]. 肝脏, 2025, 30(5): 624-629.

WANG Hui, BIAN Na-na, FENG Gong, ZHANG Fen-na, ZHANG Xin-yi, WANG Zi-yi, SUN Rong-rong, HE Na. EGF rs4444903 gene polymorphism is associated with the risk of HCV infection-related hepatocellular carcinoma: a Meta-analysis[J]. Chinese Hepatolgy, 2025, 30(5): 624-629.

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