肝细胞癌筛查中甲胎蛋白阈值的再思考

摘要/Abstract

摘要： 肝细胞癌(HCC)的早期筛查是改善预后的关键,甲胎蛋白(AFP)联合超声仍是目前临床的主流筛查方案。随着代谢相关脂肪性肝病、酒精性肝病发病率的增加,传统AFP≥20 ng/mL阈值灵敏度不足、漏诊率偏高的问题日益突出。下调阈值可显著提升肝癌检出率,但部分HCC仍为AFP阴性。本文系统梳理AFP阈值调整的研究进展与争议,提出分层、多标志物整合的优化方向,为完善 HCC 早期筛查体系、推动临床实践与指南更新提供依据。

关键词: 肝细胞癌, 甲胎蛋白, 筛查, 阈值

冒慧, 余姣. 肝细胞癌筛查中甲胎蛋白阈值的再思考[J]. 肝脏, 2026, 31(5): 602-605.

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