郑州市23 069例磁微粒化学发光法HBsAg和抗-HBs检测结果分析

摘要/Abstract

摘要： 目的应用磁微粒化学发光法了解郑州地区人群乙型肝炎感染情况,并分析检测结果和特征。方法选取2022年1月到2023年12月期间在郑州市第二人民医院进行乙型肝炎病毒血清标志物检测的23 069例数据并进行统计学分析。结果 23 069例就诊者中,检出HBsAg阳性1 266例(5.49%),其中男性阳性率(6.22%)明显高于女性(4.74%),差异有统计学意义(χ²=24.42,P<0.05);不同年度患者HBsAg阳性率比较,差异无统计学意义(χ²=0.24,P>0.05)。不同年度男性阳性率均大于女性阳性率,差异有统计学意义(χ²=5.11,21.31,P<0.05)。检出抗-HBs阳性13 681例(59.30%),其中女性阳性率(60.78%)高于男性(57.86%),差异有统计学意义(χ²=20.29,P<0.05),不同年度不同性别各年龄组的抗-HBs阳性率比较,差异均有统计学意义(χ²=43.16、103.18、30.40、100.21、250.76,P<0.05)。结论郑州地区男性HBsAg阳性率高于女性,而女性抗-HBs阳性率高于男性。郑州人群的乙型肝炎抗体保护力不足,提示有待加强主动免疫。

关键词: 乙型肝炎病毒, 乙型肝炎表面抗原, 乙型肝炎表面抗体, 磁微粒化学发光法

Abstract: Objective To investigate the status and characteristics of patients with hepatitis B viral infection in Zhengzhou area by magnetic particle chemiluminescence method. Methods The data of 23 069 cases with detected HBV serum markers from January 2022 to December 2023 in the Second Peoples Hospital of Zhengzhou were selected for statistical analysis. Results There were 1 266 HBsAg positive cases (5.49%) were detected from the 23,069 patients. The positive rate in male (6.22%) was significantly higher than that in female (4.74%), and the difference was statistically significant (χ²=24.42, P<0.05). There was no significant difference in the positive rate of HBsAg in different years (χ²=0.24, P>0.05). The positive rate of male was higher than that of female in different years, and the difference was statistically significant (χ²=5.11、21.31, P<0.05). There were 13,681 anti-HBs positive cases (59.30%) were detected from the 23,069 patients, and the positive rate in women (60.78%) was higher than that in men (57.86%), the difference was statistically significant (χ²=20.29, P<0.05), The anti-HBs positive rates of the cases in different years, genders and ages were statistically significant (χ²=43.16, 103.18, 30.40, 100.21, 250.76, P<0.05). Conclusion The positive rate of HBsAg in male was higher than that in female, and the positive rate of anti-HBs in female was higher than that in male in Zhengzhou. The high protective capacity of hepatitis B antibody in Zhengzhou population is insufficient, suggesting that active immunity for HBV infection should be strengthened.

Key words: Hepatitis B virus, Hepatitis B virus surface antigen, Hepatitis B surface antibody, Magnetic particle chemiluminescence method

田振英, 陈妍. 郑州市23 069例磁微粒化学发光法HBsAg和抗-HBs检测结果分析[J]. 肝脏, 2026, 31(5): 643-647.

TIAN Zhen-ying, CHEN Yan. An analysis on the quantitative tests of HBsAg and anti-HBs levels with magnetic particle chemiluminescence method in 23 069 different cases in Zhengzhou[J]. Chinese Hepatolgy, 2026, 31(5): 643-647.

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