铁死亡在非酒精性脂肪性肝病中的发病机制及其研究进展

摘要/Abstract

摘要： 随着肥胖患病率的升高和人口老龄化的加剧,非酒精性脂肪性肝病(NAFLD)的发病率持续上升,其疾病发展从单纯性脂肪肝进展至非酒精性脂肪性肝炎、肝纤维化、肝硬化乃至肝细胞癌。目前,NAFLD的发病机制尚不完全清楚。近年来,铁死亡作为一种新的非凋亡性细胞死亡形式,以铁依赖性脂质过氧化、活性氧累积及铁稳态失衡为特征,被证实参与NAFLD的发生与发展。针对铁死亡关键节点的多维干预,可能成为未来抗纤维化与抗恶性转化的核心方向。因此,本文重点探讨NAFLD的病理生理过程中,铁死亡如何触发和推动疾病进展,以及本领域的最新研究进展,为靶向铁死亡治疗NAFLD提供新视角、新思路。

关键词: 铁死亡, 非酒精性脂肪性肝病, 氧化应激, 脂质过氧化

张琳婧, 杨躍鑫, 张晨雨, 李可, 福娜英, 徐文静. 铁死亡在非酒精性脂肪性肝病中的发病机制及其研究进展[J]. 肝脏, 2026, 31(6): 909-913.

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