关键词: 自身免疫性肝炎, 临床病理特征, 治疗效果, 儿童

Abstract: Objective To investigate the clinicopathological features and therapies of autoimmune hepatitis (AIH) in childhood.Methods Clinical data of 82 children with AIH who were treated in our hospital from January 2017 to December 2018 were retrospectively analyzed. The children were divided into AIH type I group and AIH type II group according to the classification criteria. The clinical data of patients were collected from hospital information management system, and the differences in pathogenesis, biochemical indicators, clinical manifestations, therapeutic effects and pathological characteristics between the 2 groups were analyzed. Results The total bilirubin of AIH type I group was 52.16 ± 15.21 μmol/L, which was significantly lower than that of AIH type II group (97.64 ± 18.40 μmol/L). The immunoglobulin G of AIH type I group was 27.69 ± 3.47 g/L, which was significantly higher than that of AIH Type II group (18.25 ± 2.14 g/L). And the differences were statistically significant (P < 0.05). The infiltration ratio of lymphocytes or plasma cells in AIH type I group was 79.31%, which was significantly higher than that in AIH type II group of 16.67%. The composition ratio of interface hepatitis in AIH type I group was 17.24%, which was significantly lower than that in AIH type II group of 79.17%. And the differences were statistically significant (P<0.05). There were 12 cases of completely remission (CR) and 29 cases of partial remission (PR) in AIH type I group, 5 cases of CR and 11 cases of PR in AIH type II group. The effective rate was 70.69% in type I group, 66.67% in type II group, and the difference between the 2 groups was not statistically significant (P>0.05).Conclusion The incidence of AIH type I in childhood was higher than that of type II, and the biochemical parameters and pathological characteristics of children with different types of AIH were significantly different. The infiltration of lymphocytes or plasma cells, and interface hepatitis were relatively serious in children. After treatment, the curative effect was significant, with no significant difference in different types.

Key words: Autoimmune hepatitis, Clinicopathological features, Therapeutic effect, Children