慢性HBV携带状态自然转归的研究

肝脏 ›› 2016, Vol. 21 ›› Issue (9): 755-757.

慢性HBV携带状态自然转归的研究

刘娜, 武琼, 徐光华, 李春霞, 任婷婷, 吴殿磊

716000 陕西延安大学附属医院感染病科

收稿日期:2015-12-28 出版日期:2016-09-30 发布日期:2020-06-19
通讯作者: 徐光华,Email:yaxugh@163.com
基金资助:
延安市惠民计划项目(2014HM-09)

Received:2015-12-28 Online:2016-09-30 Published:2020-06-19

摘要/Abstract

摘要： 目的通过纵向随访慢性HBV携带状态者的临床资料,探讨其临床特征,分析其不同转归的相关预测因子。方法用实时荧光定量聚合酶链反应(FQ-PCR)及时间分辨荧光免疫分析(TRFIA)技术检测218例慢性HBV感染者血清中HBV DNA、HBsAg、HBeAg含量,用速率法检测ALT水平。结果随访时间为1年～10年,中位随访时间4.5年。至随访终点共有63例(28.90%)从免疫耐受状态过渡到免疫清除状态,性别、年龄、家族史、饮酒史可影响慢性HBV感染临床转归。结论慢性HBV携带状态患者应定期随访,可根据相关预测因素采取个体化管理。

刘娜, 武琼, 徐光华, 李春霞, 任婷婷, 吴殿磊. 慢性HBV携带状态自然转归的研究[J]. 肝脏, 2016, 21(9): 755-757.

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