从HBV X蛋白的生物学功能看靶向HBx临床治愈慢性乙型肝炎的可能性

摘要/Abstract

摘要： HBx是乙型肝炎病毒基因组编码的一种具有转录调节活性的非结构蛋白,对从头感染初始阶段新形成cccDNA转录的激活和感染过程中cccDNA转录活性的维持都具有重要作用。其中,cccDNA是HBx表达的重要转录来源,但最早的HBx从何而来仍然未知。在HBV慢性感染过程中普遍存在HBV基因组片段的整合,已有大量数据显示,整合的HBV DNA片段所表达的表面抗原蛋白是HBeAg阴性慢性乙型肝炎(CHB)患者血清HBsAg的主要来源;而其表达的保留了结合宿主细胞因子部分功能的截短HBx是否仍有激活和维持cccDNA转录的作用还有待验证。近年来,以HBx为治疗靶点的抗HBV治疗研究也取得了诸多新进展,为CHB的临床治愈提出了新的靶标。

关键词: 乙型肝炎病毒, HBx蛋白, 病毒复制, 靶向治疗

许梓萌, 李德瑶, 席婧媛, 鲁凤民. 从HBV X蛋白的生物学功能看靶向HBx临床治愈慢性乙型肝炎的可能性[J]. 肝脏, 2021, 26(8): 832-834.

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